Before Using

Drug information provided by: Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of clozapine in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clozapine in the elderly. However, elderly patients are more likely to have constipation, trouble passing urine, uncontrolled movements, or age-related liver, kidney, or heart problems, which may require caution in patients receiving clozapine. This medicine should not be used for behavioral problems in older adults with dementia.

Pregnancy

Information about this clozapine-oral-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Cisapride
  • Dronedarone
  • Droperidol
  • Fluconazole
  • Ketoconazole
  • Mesoridazine
  • Metoclopramide
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Alfuzosin
  • Amiodarone
  • Amoxapine
  • Amprenavir
  • Apomorphine
  • Aprepitant
  • Armodafinil
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Balofloxacin
  • Bedaquiline
  • Bepridil
  • Besifloxacin
  • Boceprevir
  • Bosentan
  • Bupropion
  • Buspirone
  • Caffeine
  • Carbamazepine
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Cimetidine
  • Cinacalcet
  • Cinoxacin
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Cobicistat
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Darunavir
  • Dasatinib
  • Deferasirox
  • Dexamethasone
  • Diltiazem
  • Disopyramide
  • Disulfiram
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Efavirenz
  • Enoxacin
  • Enzalutamide
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Ethinyl Estradiol
  • Etravirine
  • Famotidine
  • Fingolimod
  • Flecainide
  • Flumequine
  • Fluoxetine
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Hydromorphone
  • Hydroquinidine
  • Ibutilide
  • Iloperidone
  • Imatinib
  • Indinavir
  • Itraconazole
  • Ivabradine
  • Lapatinib
  • Levofloxacin
  • Lithium
  • Lomefloxacin
  • Lomitapide
  • Lopinavir
  • Lumefantrine
  • Mate
  • Mefloquine
  • Methadone
  • Methoxsalen
  • Mexiletine
  • Mibefradil
  • Miconazole
  • Mifepristone
  • Milnacipran
  • Mitotane
  • Mizolastine
  • Modafinil
  • Montelukast
  • Moricizine
  • Moxifloxacin
  • Nadifloxacin
  • Nafcillin
  • Nalidixic Acid
  • Nefazodone
  • Nelfinavir
  • Nevirapine
  • Nilotinib
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Omeprazole
  • Oxcarbazepine
  • Oxolinic Acid
  • Paliperidone
  • Pasireotide
  • Pazopanib
  • Pazufloxacin
  • Pefloxacin
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Perphenazine
  • Phenobarbital
  • Phenylpropanolamine
  • Phenytoin
  • Pipemidic Acid
  • Pixantrone
  • Prednisone
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propranolol
  • Protriptyline
  • Prulifloxacin
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Regorafenib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rosoxacin
  • Rufinamide
  • Rufloxacin
  • Salmeterol
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Siltuximab
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St John's Wort
  • Sunitinib
  • Tacrolimus
  • Tegafur
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Terbinafine
  • Teriflunomide
  • Tetrabenazine
  • Thiabendazole
  • Ticagrelor
  • Ticlopidine
  • Tipranavir
  • Topiramate
  • Toremifene
  • Trazodone
  • Trifluoperazine
  • Trimipramine
  • Umeclidinium
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Verapamil
  • Vinflunine
  • Voriconazole
  • Zileuton
  • Zotepine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice
  • Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Caffeine

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, history of or
  • Blood clotting problems (eg, deep vein thrombosis, pulmonary embolism) or
  • Blood vessel problems (poor circulation) or
  • Head injury, history of or
  • Heart attack, recent or history of or
  • Heart disease or
  • Heart failure or
  • Heart rhythm problems (eg, arrhythmia, long QT syndrome, slow heart rate), or history of or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypotension (low blood pressure) or
  • Lung problems or
  • Stroke, history of—May cause side effects to become worse.
  • Blood diseases (eg, agranulocytosis, granulocytopenia), history of or
  • Bone marrow disorder or
  • Intestinal blockage (eg, paralytic ileus) or
  • Seizures (epilepsy), poorly controlled—Should not be used in patients with these conditions.
  • Bowel problems (eg, constipation) or
  • Diabetes or
  • Difficult urination or
  • Dyslipidemia (high fat in the blood) or
  • Enlarged prostate or
  • Glaucoma, narrow angle or
  • Hyperglycemia (high blood sugar) or
  • Liver disease (eg, hepatitis) or
  • Neuroleptic malignant syndrome, history of or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Phenylketonuria (PKU)—The orally disintegrating tablet contains phenylalanine, which can make this condition worse.