Before Using

Drug information provided by: Micromedex

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of carbonic anhydrase inhibitors in children with use in other age groups, these medicines are not expected to cause different side effects or problems in children than they do in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of carbonic anhydrase inhibitors in the elderly with use in other age groups, these medicines are not expected to cause different side effects or problems in older people than they do in younger adults.

Pregnancy

Carbonic anhydrase inhibitors have not been studied in pregnant women. However, studies in animals have shown that carbonic anhydrase inhibitors cause birth defects. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breastfeeding

Carbonic anhydrase inhibitors may pass into the breast milk. These medicines are not recommended during breast-feeding, because they may cause unwanted effects in nursing babies. It may be necessary for you to use another medicine or to stop breast-feeding during treatment. Be sure you have discussed this with your doctor.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

  • Methenamine

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Arsenic Trioxide
  • Carbamazepine
  • Ceritinib
  • Dabrafenib
  • Digitalis
  • Droperidol
  • Eslicarbazepine Acetate
  • Idelalisib
  • Levomethadyl
  • Metformin
  • Mitotane
  • Piperaquine
  • Proscillaridin
  • Quinidine
  • Siltuximab
  • Sotalol

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

  • Type 2 diabetes mellitus—Use of carbonic anhydrase inhibitors may increase the patient's blood and urine sugar concentrations.
  • Emphysema or other chronic lung disease—Use of carbonic anhydrase inhibitors may increase the risk of acidosis (shortness of breath, troubled breathing).
  • Gout or
  • Low blood levels of potassium or sodium—Use of carbonic anhydrase inhibitors may make the condition worse.
  • Kidney disease or stones—Higher blood levels of carbonic anhydrase inhibitors may result, which may increase the chance of side effects Also, these medicines may make the condition worse.
  • Liver disease—Use of carbonic anhydrase inhibitors may increase the risk of electrolyte imbalance and may make the condition worse.
  • Underactive adrenal gland (Addison's disease)—Use of carbonic anhydrase inhibitors may increase the risk of electrolyte imbalance.