Side Effects

Drug information provided by: Micromedex

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common-Entacapone

  1. Twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

Incidence not known-Carbidopa and Levodopa and/or Levodopa alone

  1. Bleeding gums
  2. bloody or black, tarry stools
  3. bloody or cloudy urine
  4. change in size, shape, or color of an existing mole
  5. changes in skin color
  6. chest pain, discomfort, or tightness
  7. constipation
  8. constricted pupil
  9. convulsions
  10. cough
  11. difficult or labored breathing
  12. difficulty with speaking
  13. drooling
  14. drooping eyelid (ptosis)
  15. facial dryness
  16. fast, irregular, or pounding heartbeat
  17. fever with or without chills
  18. general feeling of illness
  19. hallucinations (seeing, hearing, or feeling things that are not there)
  20. hoarseness
  21. high or low blood pressure
  22. large, flat, blue, or purplish patches in the skin
  23. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  24. loss of appetite
  25. loss of bladder control
  26. lower abdominal or stomach pain
  27. lower back or side pain
  28. mole that leaks fluid or bleeds
  29. muscle cramps or spasms
  30. muscle pain or stiffness
  31. muscle trembling, jerking, or stiffness
  32. nausea
  33. pain
  34. painful or difficult urination
  35. pinpoint red spots on the skin
  36. raised red swellings on the skin, the buttocks, legs, or ankles
  37. restlessness
  38. seizures
  39. severe mental changes
  40. shakiness and unsteady walk
  41. shuffling walk
  42. sore throat
  43. sores, ulcers, or white spots on the lips or in the mouth
  44. sweating
  45. swollen glands
  46. trembling, or other problems with muscle control or coordination
  47. unusual bleeding or bruising
  48. unusual tiredness or weakness
  49. vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common-Entacapone

  1. Absence of or decrease in body movement
  2. diarrhea
  3. dizziness
  4. urine discoloration

Less common-Entacapone

  1. Acid or sour stomach
  2. anxiety
  3. belching
  4. bitter, sour, or unusual taste in the mouth
  5. bloated
  6. burning feeling in the chest or stomach
  7. dry mouth
  8. excess air or gas in the stomach or intestines
  9. fear
  10. full feeling
  11. heartburn
  12. hyperventilation
  13. increased sweating
  14. indigestion
  15. irritability
  16. lack or loss of strength
  17. nervousness
  18. passing gas
  19. restlessness
  20. sleepiness or unusual drowsiness
  21. stomach discomfort or upset
  22. swollen mouth and tongue
  23. tenderness in the stomach area
  24. trouble sleeping
  25. urge to have bowel movement
  26. wheezing

Incidence not known-Carbidopa and Levodopa and/or Levodopa alone

  1. Being forgetful
  2. bladder pain
  3. blurred vision
  4. body aches or pain
  5. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  6. burning and upper abdominal or stomach pain
  7. burning sensation of the tongue
  8. clenching, gnashing, or grinding teeth
  9. confusion about identity, place, and time
  10. dark saliva
  11. dark sweat
  12. decreased mental acuity
  13. difficulty swallowing
  14. discouragement
  15. double vision
  16. ear congestion
  17. enlarged pupils
  18. excessive watering of the mouth
  19. fainting
  20. false or unusual sense of well-being
  21. feeling like you will pass out
  22. feeling of warmth
  23. feeling sad or empty
  24. flushing
  25. hair loss
  26. headache
  27. hiccups
  28. hives or welts
  29. increased blinking
  30. increased interest in sexual ability, desire, drive, or performance
  31. increased interest in sexual intercourse
  32. lack of appetite
  33. large, hard skin blisters
  34. leg pain
  35. loss of voice
  36. muscle spasm, especially of the neck and back
  37. nasal congestion
  38. nightmares
  39. numbness
  40. pain in the chest below the breastbone
  41. painful or prolonged erection of the penis
  42. pharyngeal pain
  43. pounding in the ears
  44. problems with memory or speech
  45. redness of the face, neck, arms, and occasionally upper chest
  46. runny nose
  47. sense of stimulation
  48. skin rash
  49. sleeplessness
  50. slow movement
  51. slow or fast heartbeat
  52. slow reflexes
  53. sneezing
  54. swelling
  55. tremor, increased
  56. trouble concentrating
  57. trouble recognizing objects
  58. trouble thinking and planning
  59. urinary frequency
  60. urinary retention
  61. weight gain
  62. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.