Before Using

Drug information provided by: Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of captopril and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established .

Geriatric

No information is available on the relationship of age to the effects of captopril and hydrochlorothiazide combination in geriatric patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dose in patients receiving captopril and hydrochlorothiazide combination .

Pregnancy

Information about this captopril-and-hydrochlorothiazide-oral-route
Pregnancy Category Explanation
1st Trimester C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
3rd Trimester D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Aliskiren
  • Dofetilide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetyldigoxin
  • Afatinib
  • Allopurinol
  • Alteplase, Recombinant
  • Amiloride
  • Arsenic Trioxide
  • Azathioprine
  • Azilsartan
  • Bosutinib
  • Candesartan Cilexetil
  • Canrenoate
  • Cyclophosphamide
  • Dabigatran Etexilate
  • Deslanoside
  • Digitalis
  • Digitoxin
  • Digoxin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Eplerenone
  • Eprosartan
  • Everolimus
  • Flecainide
  • Interferon Alfa-2a
  • Irbesartan
  • Ketanserin
  • Levomethadyl
  • Lithium
  • Losartan
  • Methotrexate
  • Metildigoxin
  • Morphine
  • Morphine Sulfate Liposome
  • Nilotinib
  • Olmesartan Medoxomil
  • Ouabain
  • Pixantrone
  • Pomalidomide
  • Potassium
  • Proscillaridin
  • Romidepsin
  • Sotalol
  • Spironolactone
  • Telmisartan
  • Topotecan
  • Trabectedin
  • Triamterene
  • Valsartan
  • Vincristine
  • Vincristine Sulfate Liposome

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Alacepril
  • Amtolmetin Guacil
  • Aspirin
  • Azosemide
  • Bemetizide
  • Benazepril
  • Bendroflumethiazide
  • Benzthiazide
  • Bepridil
  • Bromfenac
  • Bufexamac
  • Bumetanide
  • Bupivacaine
  • Bupivacaine Liposome
  • Buthiazide
  • Capsaicin
  • Captopril
  • Carbamazepine
  • Celecoxib
  • Chlorothiazide
  • Chlorpromazine
  • Chlorpropamide
  • Chlorthalidone
  • Cholestyramine
  • Choline Salicylate
  • Cilazapril
  • Clonixin
  • Clopamide
  • Cyclopenthiazide
  • Cyclothiazide
  • Delapril
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digoxin
  • Dipyrone
  • Enalaprilat
  • Enalapril Maleate
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fosinopril
  • Furosemide
  • Ginkgo
  • Glipizide
  • Gold Sodium Thiomalate
  • Gossypol
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibuprofen
  • Ibuprofen Lysine
  • Icatibant
  • Imidapril
  • Indapamide
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lisinopril
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Methyclothiazide
  • Metolazone
  • Moexipril
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Nesiritide
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Pentopril
  • Perindopril
  • Phenylbutazone
  • Piketoprofen
  • Piretanide
  • Piroxicam
  • Polythiazide
  • Pranoprofen
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quinapril
  • Quinethazone
  • Ramipril
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Spirapril
  • Sulindac
  • Temocapril
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Topiramate
  • Torsemide
  • Trandolapril
  • Trichlormethiazide
  • Valdecoxib
  • Xipamide
  • Zofenopril

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angioedema, history of—May increase the risk of this condition occurring again .
  • Anuria (not able to pass urine)—This medicine should not be used in patients with this condition .
  • Asthma, bronchial—This medicine may cause sensitivity reactions .
  • Dehydration or
  • Diarrhea or
  • Heart failure or
  • Hyponatremia (low sodium in the blood) or
  • Kidney disease—These conditions may cause the blood pressure to fall too low with this medicine .
  • Diabetes or
  • Gout or
  • Hyperuricemia (high uric acid in the blood) or
  • Liver disease or
  • Systemic lupus erythematosus (SLE)—These conditions may be made worse .