Proper Use

Drug information provided by: Micromedex

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Aprepitant is given together with other medicines to prevent vomiting from chemotherapy. Carefully follow your doctor's instructions about how to take the medicines.

You may take this medicine with or without food.

Swallow the capsule whole. Do not crush, break, or chew it.

To use the oral suspension:

  • For each dose of this medicine, you will receive a prefilled oral dosing dispenser that contains your prescribed dose.
  • Call your doctor right away if you or your child is not able to take the prescribed dose.
  • Throw away the oral dosing dispenser and cap after each use.

Do not start taking aprepitant if you already have nausea and vomiting. Contact your doctor about what to do.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For prevention of nausea and vomiting caused by chemotherapy:
      • Adults and children 12 years of age and older—125 milligrams (mg) 1 hour before chemotherapy (Day 1). Then, 80 mg once in the morning on Days 2 and 3.
      • Children younger than 12 years of age, weighing at least 30 kilograms (kg), and can swallow a capsule—125 mg 1 hour before chemotherapy (Day 1). Then, 80 mg once in the morning on Days 2 and 3.
      • Children younger than 12 years of age weighing less than 30 kg—Use and dose must be determined by your doctor.
    • For prevention of nausea and vomiting after surgery:
      • Adults—40 milligrams (mg) within 3 hours before surgery.
      • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (powder for suspension):
    • For prevention of nausea and vomiting caused by chemotherapy:
      • Adults and children 6 months to 11 years of age and cannot swallow the capsule—Dose is based on body weight and must be determined by your doctor. The dose is usually 3 milligrams (mg) per kilogram (kg) of body weight up to a maximum dose of 125 mg taken 1 hour before chemotherapy (Day 1). Then, 2 mg per kg of body weight up to a maximum dose of 80 mg taken once in the morning on Days 2 and 3.
      • Children younger than 6 months of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the oral liquid in the oral dosing dispenser in the refrigerator for up to 72 hours before use. You may also keep the medicine at room temperature for up to 3 hours.