Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of amlodipine and valsartan combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amlodipine and valsartan combination in the elderly. However, elderly patients may be more sensitive to the effects of this medicine than younger adults, which may require caution in patients receiving amlodipine and valsartan combination.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Aliskiren
  • Sparsentan

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Asciminib
  • Atazanavir
  • Benazepril
  • Captopril
  • Carbamazepine
  • Ceritinib
  • Cilazapril
  • Clarithromycin
  • Clopidogrel
  • Conivaptan
  • Cyclosporine
  • Dantrolene
  • Darolutamide
  • Darunavir
  • Digoxin
  • Domperidone
  • Droperidol
  • Eltrombopag
  • Enalapril
  • Enalaprilat
  • Epirubicin
  • Erythromycin
  • Fedratinib
  • Fexinidazole
  • Fosinopril
  • Fosnetupitant
  • Furosemide
  • Itraconazole
  • Lacosamide
  • Lisinopril
  • Lithium
  • Mavacamten
  • Melphalan
  • Moexipril
  • Netupitant
  • Omaveloxolone
  • Perindopril
  • Phenobarbital
  • Piperaquine
  • Potassium Citrate
  • Potassium Phosphate
  • Primidone
  • Quinapril
  • Ramipril
  • Rifampin
  • Ritonavir
  • Simeprevir
  • Simvastatin
  • Spirapril
  • Tacrolimus
  • Tegafur
  • Telaprevir
  • Trandolapril
  • Trimethoprim
  • Zofenopril

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Amprenavir
  • Amtolmetin Guacil
  • Aprepitant
  • Boceprevir
  • Bromfenac
  • Bufexamac
  • Celecoxib
  • Choline Salicylate
  • Cimetidine
  • Ciprofloxacin
  • Clofazimine
  • Clonixin
  • Cobicistat
  • Crizotinib
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Diltiazem
  • Dipyrone
  • Dronedarone
  • Droxicam
  • Duvelisib
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Flurbiprofen
  • Fluvoxamine
  • Fosamprenavir
  • Ibuprofen
  • Idelalisib
  • Indinavir
  • Indomethacin
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Letermovir
  • Lonafarnib
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Mifepristone
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nefazodone
  • Nelfinavir
  • Nepafenac
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Posaconazole
  • Pranoprofen
  • Proglumetacin
  • Propionic Acid
  • Propyphenazone
  • Proquazone
  • Ribociclib
  • Rifapentine
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Schisandra sphenanthera
  • Sodium Salicylate
  • Sulindac
  • Telithromycin
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Troleandomycin
  • Tucatinib
  • Valdecoxib
  • Verapamil
  • Voriconazole
  • Voxelotor

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (severe chest pain) or
  • Electrolyte imbalances (e.g., low sodium in the body) or
  • Fluid imbalances (caused by dehydration, vomiting, or diarrhea) or
  • Heart attack, recent or
  • Heart problems (e.g., aortic stenosis, heart failure) or
  • Kidney problems or
  • Patients undergoing surgery or dialysis—Use with caution. May make these conditions worse.
  • Congestive heart failure, severe—Use may lead to kidney problems.
  • Angioedema (an allergic reaction) with other blood pressure medicines (e.g., benazepril, enalapril, lisinopril, Lotrel®, Vasotec®, Zestoretic®, Zestril®), history of or
  • Diabetes patients who are also taking aliskiren (Tekturna®)—Should not be used in these patients.
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Portions of this document last updated: May 01, 2024

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