Tetralogy of Fallot occurs during fetal growth, when the baby's heart is developing. While factors such as poor maternal nutrition, viral illness or genetic disorders might increase the risk of this condition, in most cases the cause of tetralogy of Fallot is unknown.
The four abnormalities that make up the tetralogy of Fallot include:
Pulmonary valve stenosis. Pulmonary valve stenosis is a narrowing of the pulmonary valve — the valve that separates the lower right chamber of the heart (right ventricle) from the main blood vessel leading to the lungs (pulmonary artery).
Narrowing (constriction) of the pulmonary valve reduces blood flow to the lungs. The narrowing might also affect the muscle beneath the pulmonary valve.
Ventricular septal defect. A ventricular septal defect is a hole in the wall that separates the two lower chambers of the heart — the left and right ventricle. The hole allows deoxygenated blood in the right ventricle — blood that has circulated through the body and is returning to the lungs to replenish its oxygen supply — to flow into the left ventricle and mix with oxygenated blood fresh from the lungs.
Blood from the left ventricle also flows back to the right ventricle in an inefficient manner. This ability for blood to flow through the ventricular septal defect reduces the supply of oxygenated blood to the body and eventually can weaken the heart.
Overriding aorta. Normally the aorta — the main artery leading out to the body — branches off the left ventricle. In tetralogy of Fallot, the aorta is shifted slightly to the right and lies directly above the ventricular septal defect.
In this position the aorta receives blood from both the right and left ventricles, mixing the oxygen-poor blood from the right ventricle with the oxygen-rich blood from the left ventricle.
- Right ventricular hypertrophy. When the heart's pumping action is overworked, it causes the muscular wall of the right ventricle to thicken. Over time this might cause the heart to stiffen, become weak and eventually fail.
Some babies who have tetralogy of Fallot may have other heart defects, such as a hole between their heart's upper chambers (atrial septal defect).
Oct. 08, 2015
- What is tetralogy of Fallot? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/tof. Accessed Aug. 4, 2015.
- Doyle T, et al. Pathophysiology, clinical features, and diagnosis of tetralogy of Fallot. http://www.uptodate.com/home. Accessed July 31, 2015.
- Doyle T, et al. Management and outcome of tetralogy of Fallot. http://www.uptodate.com/home. Accessed July 31, 2015.
- Facts about tetralogy of Fallot. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/heartdefects/TetralogyOfFallot.html. Accessed July 31, 2015.
- Tetralogy of Fallot. Merck Manual Professional Version. http://www.merckmanuals.com/professional/pediatrics/congenital-cardiovascular-anomalies/tetralogy-of-fallot. Accessed Aug. 4, 2015.
- Bonow RO, et al. Congenital heart disease. In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2015. http://www.clinicalkey.com. Accessed July 31, 2015.
- Warnes CA, et al. ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: Executive summary. Circulation. 2008;118:2395.
- Tetralogy of Fallot. American Heart Association. http://www.heart.org/HEARTORG/Conditions/CongenitalHeartDefects/AboutCongenitalHeartDefects/Tetralogy-of-Fallot_UCM_307038_Article.jsp. Accessed July 31, 2015.
- Ferri FF. Tetralogy of Fallot. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed Aug. 4, 2015.
- Finding support. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/birthdefects/families-support.html. Accessed July 31, 2015.
- Getting support. American Heart Association. http://www.heart.org/HEARTORG/Caregiver/ReachOut/GettingSupport/Getting-Support_UCM_301847_Article.jsp. Accessed Aug. 4, 2015.
- Riggin ER. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Aug. 4, 2015.
- Connolly HM (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 9, 2015.