Serotonin syndrome symptoms usually occur within several hours of taking a new drug or increasing the dose of a drug you're already taking. Signs and symptoms include:
- Agitation or restlessness
- Rapid heart rate and high blood pressure
- Dilated pupils
- Loss of muscle coordination or twitching muscles
- Muscle rigidity
- Heavy sweating
- Goose bumps
Severe serotonin syndrome can be life-threatening. Signs and symptoms include:
- High fever
- Irregular heartbeat
When to see a doctor
If you suspect you might have serotonin syndrome after starting a new drug or increasing the dose of a drug you're already taking, call your doctor right away or go to the emergency room. If you have severe or rapidly worsening symptoms, seek emergency treatment immediately.
March 13, 2014
- Tintinalli JE, et al. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. 7th ed. New York, N.Y.: The McGraw Hill Companies; 2011. http://www.accessmedicine.com/popup.aspx?aID=6385015. Accessed Sept. 12, 2013.
- Boyer EW. Serotonin syndrome. http://www.uptodate.com/home. Accessed Sept. 12, 2013.
- Iqbal MM, et al. Overview of serotonin syndrome. Annals of Clinical Psychiatry. 2012;24:310.
- Ables AZ, et al. Prevention, diagnosis, and management of serotonin syndrome. American Family Physician. 2010;81:1139.
- Information for healthcare professionals: Selective serotonin reuptake inhibitors (SSRIs), selective serotonin-norepinephrine reuptake inhibitors (SNRIs), 5-hydroxytryptamine receptor agonists (triptans). U.S. Food & Drug Administration. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm085845.htm. Accessed Sept. 16, 2013.