Your doctor will talk with you about your medical history and conduct a physical exam. No test can confirm a diagnosis of pyoderma gangrenosum. But your doctor may order a variety of tests to rule out other conditions that may have similar signs or symptoms.

  • Blood tests. A sample of your blood can be tested for evidence of infection, liver or kidney problems, and rheumatoid arthritis, among other conditions.
  • Skin biopsy. A skin biopsy involves removing a small sample of the affected skin so that it can be viewed under a microscope.
  • Colonoscopy. An examination of your colon can check for inflammatory bowel disease.
  • Imaging studies. A CT scan or chest X-ray may be used to check for deep infection or inflammation.