Diagnosis

Your doctor will talk with you about your medical history and conduct a physical exam. No test can confirm a diagnosis of pyoderma gangrenosum. But your doctor may order a variety of tests to rule out other conditions that may have similar signs or symptoms.

  • Blood tests. A sample of your blood can be tested for evidence of infection, liver or kidney problems, and rheumatoid arthritis, among other conditions.
  • Skin biopsy. A skin biopsy involves removing a small sample of the affected skin so that it can be viewed under a microscope.
  • Colonoscopy. An examination of your colon can check for inflammatory bowel disease.
  • Imaging studies. A CT scan or chest X-ray may be used to check for deep infection or inflammation.
Dec. 16, 2015
References
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  2. Miller J, et al. Pyoderma gangrenosum: A review and update on new therapies. Journal of the American Academy of Dermatology. 2010;62:646.
  3. AskMayoExpert. Pyoderma gangrenosum. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
  4. Shahi V, et al. Pyoderma gangrenosum associated with solid organ malignancies. International Journal of Dermatology. 2015;54:e351.
  5. Bolognia J, et al., eds. Neutrophilic dermatoses. In: Dermatology. 3rd ed. Philadelphia: Elsevier Saunders; 2012.
  6. Ferri FF. Pyoderma gangrenosum. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com Accessed Sept. 24, 2015.
  7. Wolff K, et al. Neutrophil-mediated diseases. In: Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology. 7th ed. New York, N.Y.: The McGraw-Hill Companies; 2013. http://www.accessmedicine.com. Accessed Sept. 29, 2015.
  8. Goldsmith LA, et al., eds. Pyoderma gangrenosum. In: Fitzpatrick's Dermatology in General Medicine. 8th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com. Accessed Sept. 29, 2015.
  9. Stanislav N, et al. Postoperative pyoderma gangrenosum (PG): The Mayo Clinic experience of 20 years from 1994 through 2014. Journal of the American Academy of Dermatology. 2015;73:615.
  10. Braswel SF, et al. Pathophysiology of pyoderma gangrenosum (PG): An updated review. Journal of the American Academy of Dermatology. 2015;73:691.
  11. Cabalag MS, et al. Inpatient management of pyoderma gangrenosum: Treatments, outcomes and clinical implications. Annals of Plastic Surgery. 2015;74:354.
  12. AskMayoExpert. Skin grafts. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
  13. Stair-Buchmann ME, et al. Pyoderma gangrenosum: A difficult diagnosis best managed in a burn treatment center. Journal of Burn Care Research. 2015;36:3190.
  14. Armstrong DG, et al. Basic principles of wound management. http://www.uptodate.com/home. Accessed Sept. 30, 2015.
  15. Okhovat JP, et al. JAMA Dermatology Patient Page: Pyoderma gangrenosum. JAMA Dermatology. 2014;150:1032.
  16. DeFilipps EM, et al. The genetics of pyoderma gangrenosum and implications for treatment: A systematic review. British Journal of Dermatology. 2015;172:1487.
  17. AskMayoExpert. Skin ulcers. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015.