Many primary immunodeficiency disorders are inherited — passed down from one or both parents. Problems in the DNA — the genetic code that acts as a blueprint for producing the cells that make up the human body — cause many of the immune system defects in primary immunodeficiency.
There are numerous types of primary immunodeficiency disorders. In fact, research has led to a dramatic increase in the number of recognized primary immunodeficiency disorders in recent years, so they're not as rare as once thought. They can be broadly classified into six groups based on the part of the immune system that's affected:
Jul. 30, 2013
- B cell (antibody) deficiencies
- T cell deficiencies
- Combination B and T cell deficiencies
- Defective phagocytes
- Complement deficiencies
- Unknown (idiopathic)
- Primary immunodeficiency. Eunice Kennedy Shriver National Institute of Child Health and Human Development. http://www.nichd.nih.gov/publications/pubs/Pages/primary_immuno.aspx. Accessed May 20, 2013.
- Blaese R, et al. Patient and Family Handbook for Primary Immunodeficiency Diseases. 4th ed. Towson, Md.: Immune Deficiency Foundation; 2007. http://primaryimmune.org/about-primary-immunodeficiency-diseases/idf-publications/patient-family-handbook. Accessed May 20, 2013.
- Primary immunodeficiency diseases. American Academy of Allergy, Asthma and Immunology. http://www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-disease.aspx. Accessed May 20, 2013.
- Papadopoulou-Alataki E, et al. Prevention of infection of children and adolescents with primary immunodeficiency disorders. Asian Pacific Journal of Allergy and Immunology. 2012;30:249.
- Pasternak MS. Approach to the adult with recurrent infections. http://www.uptodate.com/home. Accessed May 20, 2013.
- Bonilla FA. Medical management of immune deficiency. http://www.uptodate.com/home. Accessed May 20, 2013.
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