Polycystic kidney disease

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Displaying 1-10 out of 23 doctors available

  1. Andrew J. Bentall, M.B., Ch.B., M.D.

    Andrew J. Bentall, M.B., Ch.B., M.D.

    1. Nephrologist
    2. Transplant Nephrologist
    1. Rochester, MN
    Areas of focus:

    Kidney transplant, Living donor kidney transplant, Living-donor transplant, Transplant, Kidney donor evaluation, Pancre...as transplant, Preemptive kidney transplant, Simultaneous pancreas-kidney transplant, Post-transplant long-term care, Pre-transplant evaluation, Immunosuppressive drug therapy, Preoperative cardiac evaluation, Preventing infection in immunocompromised patient, Living organ donation, Paired kidney donation, Living kidney donation, Pre-kidney transplant evaluation, Post-kidney transplant care, Pre-pancreas transplant evaluation, Post-pancreas transplant care, Chronic kidney disease, Polycystic kidney disease, Nephrotic syndrome, Malignant hypertension, Hydronephrosis, Hyperoxaluria, Glomerulonephritis, IgA nephropathy, Kidney failure, Tertiary hyperparathyroidism, End-stage renal disease, Diabetic nephropathy, Hyperparathyroidism, Kidney infection, Post-transplant hypertension, Simple kidney cyst, Lupus nephritis, Secondary hyperparathyroidism, Hereditary nephritis, Secondary high blood pressure, Immunotactoid glomerulonephritis, Renovascular disease, Minimal change disease, Acute kidney injury , Renal parenchymal disease, Inherited cystic kidney disorder, Renal cell carcinoma, Metabolic acidosis, Thin basement membrane disease, Primary hyperoxaluria, Renovascular hypertension, Renal tubular acidosis, Myeloma kidney disease, Hyperphosphatemia, Renal papillary necrosis, Interstitial nephritis, Membranoproliferative glomerulonephritis, Hypertensive nephropathy, Renal amyloidosis, Metabolic kidney disease

  2. Fouad T. Chebib, M.D.

    Fouad T. Chebib, M.D.

    1. Jacksonville, FL
    Areas of focus:

    Kidney transplant, Transplant, Pancreas transplant, Kidney dialysis, High blood pressure, Chronic kidney disease, Polyc...ystic kidney disease, Kidney stone, Acute kidney failure, End-stage renal disease, Kidney cyst, Glomerular disease

  3. Carl H. Cramer, II, M.D.

    Carl H. Cramer, II, M.D.

    1. Pediatrician
    2. Transplant Nephrologist
    3. Pediatric Nephrologist
    1. Rochester, MN
    Areas of focus:

    Hemodialysis, Kidney transplant, Peritoneal dialysis, Dialysis, High blood pressure, Urinary tract infection, Chronic k...idney disease, Medullary sponge kidney, Polycystic kidney disease, High blood pressure in children, Blood in urine, Tuberous sclerosis, Nephrotic syndrome, Malignant hypertension, Hydronephrosis, Glomerulonephritis, IgA nephropathy, Kidney failure, End-stage renal disease, Focal segmental glomerulosclerosis, Kidney infection, Post-transplant hypertension, Protein in urine, Lupus nephritis, Kidney cyst, Hereditary nephritis, Secondary high blood pressure, Renal artery stenosis, Nephritis, Renovascular disease, Minimal change disease, Acute kidney injury , Nail disease, Thin basement membrane disease, Congenital kidney disorder, Single kidney, Glomerular disease, Renovascular hypertension, Kidney angiomyolipoma, Renal tubular acidosis, Interstitial nephritis, Membranoproliferative glomerulonephritis, Childhood nephrotic syndrome, Horseshoe kidney, Postural proteinuria, Multicystic kidney dysplasia, Kidney injury, Shrinking kidney

  4. Neera K. Dahl, M.D., Ph.D.

    Neera K. Dahl, M.D., Ph.D.

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    Polycystic kidney disease, Kidney stone, Polycystic liver disease, Genetic disorder

  5. Patrick G. Dean, M.D.

    Patrick G. Dean, M.D.

    1. Transplant Surgeon
    1. Rochester, MN
    Areas of focus:

    Kidney transplant, Transplant, Pancreas transplant, Islet cell transplant, Diabetes, Polycystic kidney disease, End-sta...ge renal disease, ADPKD

  6. Peter M. Fitzpatrick, M.D.

    Peter M. Fitzpatrick, M.D.

    1. Internist
    2. Nephrologist
    1. Jacksonville, FL
    Areas of focus:

    Continuous renal replacement therapy, Dialysis, Chronic kidney disease, Polycystic kidney disease, Kidney stone, Kidney... failure, End-stage renal disease

  7. Navin R. Gupta, M.D.

    Navin R. Gupta, M.D.

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    High blood pressure, Chronic kidney disease, Polycystic kidney disease, Kidney stone, Alport syndrome, Focal segmental ...glomerulosclerosis, Acute kidney injury

  8. Christian Hanna, M.D., M.S.

    Christian Hanna, M.D., M.S.

    1. Pediatric Nephrologist
    1. Rochester, MN
    Areas of focus:

    Hemodialysis, Kidney transplant, Peritoneal dialysis, Continuous renal replacement therapy, Dialysis, Urinary tract inf...ection, Chronic kidney disease, Medullary sponge kidney, Polycystic kidney disease, Kidney stone, High blood pressure in children, Blood in urine, Nephrotic syndrome, Hydronephrosis, Hemolytic uremic syndrome, IgA nephropathy, End-stage renal disease, Focal segmental glomerulosclerosis, Kidney infection, Protein in urine, Membranous nephropathy, Kidney cyst, Renal artery stenosis, Renovascular disease, Minimal change disease, Acute kidney injury , Inherited cystic kidney disorder, Congenital kidney disorder, Single kidney, Glomerular disease, Renal tubular acidosis, Membranoproliferative glomerulonephritis, Childhood nephrotic syndrome, Horseshoe kidney, Postural proteinuria, Multicystic kidney dysplasia

  9. Marie C. Hogan, M.D., Ph.D.

    Marie C. Hogan, M.D., Ph.D.

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    Polycystic kidney disease, IgA nephropathy, End-stage renal disease, Focal segmental glomerulosclerosis, Glomerular dis...ease

  10. Musab S. Hommos, M.B.B.S.

    Musab S. Hommos, M.B.B.S.

    1. Nephrologist
    1. Phoenix, AZ
    Areas of focus:

    High blood pressure, Chronic kidney disease, Polycystic kidney disease, Amyloidosis, Glomerulonephritis, End-stage rena...l disease, Renal artery stenosis, Acute kidney injury , Renal tubular acidosis

Research

Mayo Clinic is a leader in polycystic kidney disease research. Mayo Clinic researchers discovered:

  • The main gene that causes autosomal dominant polycystic kidney disease (ADPKD)
  • The gene that causes autosomal recessive polycystic kidney disease (ARPKD)
  • A gene that causes a rare form of polycystic kidney disease associated with multiple malformations (Meckel-Gruber syndrome)
  • The polycystic kidney disease proteins polycystin 1, polycystin 2 and fibrocystin
  • The polycystic kidney and liver disease gene GANAB
  • Other genes that cause kidney cyst disease, such as DNAJB11
  • A way to use CT and MRI scans to classify polycystic kidney disease and select people for clinical trials of new therapies
  • A pioneering approach to surgery to remove diseased kidneys and transplant healthy kidneys during the same surgery

Lab-based research at Mayo Clinic has focused on:

  • Explaining how mutations in the polycystic kidney disease genes lead to cyst development
  • Preclinical studies in drug therapies for polycystic kidney disease, such as octreotide and vasopressin antagonists
  • Finding effective therapies for polycystic kidney disease and liver disease
  • Improving imaging assessments of polycystic kidney and liver disease
  • Studies of polycystic kidney disease proteins in urine particles known as exosomes
  • Testing new compounds in animal models of polycystic kidney disease
  • Studies of the hairlike structures (primary cilia) implicated in polycystic kidney disease

Mayo research has shown that a new drug (tolvaptan) can dramatically slow the development and progression of polycystic kidney disease in animal models.

Mayo researchers have also shown that another drug (octreotide) delays the development of both polycystic kidney disease and polycystic liver disease and is a potential treatment option for people with liver involvement.

These medications are now in clinical trials and tolvaptan is approved for use in some countries for polycystic kidney disease. In addition, nephrologists at Mayo Clinic are working to understand how to prevent the progression of kidney (renal) disease in patients with polycystic kidney disease.

Read more about the extensive research being done at Mayo Clinic's Robert M. and Billie Kelley Pirnie Translational Polycystic Kidney Disease (PKD) Center.

The Mayo Nephrology Collaborative Group — a consortium of nephrologists located across the United States — develops and conducts studies aimed at improving treatment of patients with renal diseases, including polycystic kidney disease.

Publications

See a list of publications by Mayo Clinic doctors on polycystic kidney disease on PubMed, a service of the National Library of Medicine.

Research Profiles

By Mayo Clinic Staff

Polycystic kidney disease care at Mayo Clinic

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Diagnosis & treatmentCare at Mayo Clinic
Jan. 25, 2024
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Polycystic kidney disease

Research: It's all about patients

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Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight.