In Parkinson's disease, certain nerve cells (neurons) in the brain gradually break down or die. Many of the symptoms are due to loss of neurons that produce a chemical messenger in your brain called dopamine. When dopamine levels decrease, it causes abnormal brain activity, leading to signs of Parkinson's disease.
The cause of Parkinson's disease is unknown, but several factors appear to play a role, including:
Your genes. Researchers have identified specific genetic mutations that can cause Parkinson's disease, but these are uncommon except in rare cases with many family members affected by Parkinson's disease.
However, certain gene variations appear to increase the risk of Parkinson's disease but with a relatively small risk of Parkinson's disease for each of these genetic markers.
- Environmental triggers. Exposure to certain toxins or environmental factors may increase the risk of later Parkinson's disease, but the risk is relatively small.
In summary, more research needs to be done to identify the factors causing Parkinson's disease.
Many changes occur in the brains of people with Parkinson's disease, including:
May 28, 2014
- The presence of Lewy bodies. Clumps of specific substances within brain cells are microscopic markers of Parkinson's disease. These are called Lewy bodies, and researchers believe these Lewy bodies hold an important clue to the cause of Parkinson's disease.
- A-synuclein is found within Lewy bodies. Although many substances are found within Lewy bodies, scientists believe the most important of these is the natural and widespread protein called alpha-synuclein. It's found in all Lewy bodies in a clumped form that cells can't break down. This is currently an important focus among Parkinson's disease researchers.
- Parkinson's disease: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/parkinsons_disease/parkinsons_disease.htm. Accessed Aug. 8, 2013.
- Chou KL. Clinical manifestations of Parkinson disease. http://www.uptodate.com/home. Accessed Aug. 8, 2013.
- Jankovic J. Etiology and pathogenesis of Parkinson disease. http://www.uptodate.com/home. Accessed Aug. 8, 2013.
- Chou KL. Diagnosis of Parkinson disease. http://www.uptodate.com/home. Accessed Aug. 8, 2013.
- Tarsy D. Pharmacologic treatment of Parkinson disease. http://www.uptodate.com/home. Accessed Aug. 8, 2013.
- Tarsy D. Surgical treatment of Parkinson disease. http://www.uptodate.com/home. Accessed Aug. 8, 2013.
- Tarsy D. Nonpharmacologic management of Parkinson disease. http://www.uptodate.com/home/. Accessed Aug. 8, 2013.
- Ahlskog JE. Does vigorous exercise have a neuroprotective effect in Parkinson disease? Neurology. 2011;77:288.
- Rakel D. Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com/. Accessed Aug. 12, 2013.
- Parkinson's disease: Fitness counts. National Parkinson Foundation. http://www.parkinson.org/Search-Pages/Search.aspx?pKeywords=fitness. Accessed Aug. 12, 2013.
- Mischley LY, et al. Coenzyme Q10 deficiency in patients with Parkinson's disease. Journal of the Neurological Sciences. 2012;318:72.
- Li F., et al. Tai chi and postural stability in patients with Parkinson's disease. The New England Journal of Medicine. 2012;366:511.
- Complementary therapies and Parkinson's. Parkinson's Disease Society of the United Kingdom. http://www.parkinsons.org.uk/content/complementary-therapies-and-parkinsons-booklet. Accessed Aug. 12, 2013.
- Riggin EA. Decision Support System. Mayo Clinic, Rochester, Minn. Aug. 13, 2013.
- Saliva gland test for Parkinson's shows promise, study finds. Mayo Clinic. http://www.mayoclinic.org/news2013-sct/7249.html. Accessed Aug. 15, 2013.
- Ahlskog JE (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 5, 2013.