Overview

Paget's disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, the disease can cause affected bones to become fragile and misshapen. Paget's disease of bone most commonly occurs in the pelvis, skull, spine and legs.

The risk of Paget's disease of bone increases with age. Your risk also increases if any family members have the disorder. Complications of Paget's disease of bone can include broken bones, hearing loss and pinched nerves in your spine.

Bisphosphonates — the medications also used to strengthen bones weakened by osteoporosis — are the mainstay of treatment. In severe cases, surgery may be necessary.

Feb. 11, 2016
References
  1. Seton M. Clinical manifestations and diagnosis of Paget disease of bone. http://www.uptodate.com/home. Accessed Nov. 11, 2015.
  2. Singer FR, et al. Paget's disease of the bone: An Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism. 2014;99:1.
  3. What is Paget's disease of bone? National Institutes of Health Osteoporosis and Related Bone Diseases: National Resource Center. http://www.niams.nih.gov/Health_Info/Bone/Pagets/pagets_disease_ff.asp. Accessed Nov. 11, 2015.
  4. Seton M. Treatment of Paget disease of bone. http://www.uptodate.com/home. Accessed Nov. 11, 2015.