Ovarian hyperstimulation syndrome generally resolves on its own within a week or two or somewhat longer if you're pregnant. Treatment is aimed at keeping you comfortable, decreasing ovarian activity and avoiding complications.
Mild to moderate OHSS
Mild OHSS typically resolves on its own. Treatment for moderate OHSS may involve:
- Anti-nausea medication, prescription painkillers or both
- Frequent physical exams and ultrasounds
- Daily weigh-ins and waist measurements to check for drastic changes
- Measuring how much urine you produce each day
- Blood tests to monitor for dehydration, electrolyte imbalance and other problems
- Drinking sufficient fluids
- Draining excess abdominal fluid using a needle inserted in your abdominal cavity
- Wearing support stockings to help prevent blood clots
With severe OHSS, you may need to be admitted to the hospital for monitoring and aggressive treatment, including intravenous (IV) fluids. Your doctor may give you a medication called cabergoline to lessen your symptoms. In some cases, your doctor may also give you another medication — known as a Gn-RH antagonist — to help suppress ovarian activity.
Serious complications may require additional treatments, such as surgery for a ruptured ovarian cyst or intensive care for liver or lung complications. You may also need anticoagulant medications to decrease the risk of blood clots in your legs.
Feb. 14, 2014
- Gera PS, et al. Ovarian hyperstimulation syndrome: Steps to maximize success and minimize effect for assisted reproductive outcome. Fertility and Sterility. 2010;94:173.
- Insler V, et al. Pathogenesis of ovarian hyperstimulation syndrome. http://www.uptodate.com/home Accessed Sept. 23, 2013.
- Shaw RW, et al. Gynaecology. 4th ed. Edinburgh, U.K.: Churchill Livingstone; 2011. http://www.clinicalkey.com. Accessed Sept. 24, 2013.
- Vloeberghs V, et al. Ovarian hyperstimulation syndrome and complications of ART. Best Practice & Research Clinical Obstetrics and Gynaecology. 2009;23:691.
- Insler V, et al. Classification and treatment of ovarian hyperstimulation syndrome. http://www.uptodate.com/home. Accessed Sept. 23, 2013.
- Lentz GM, et al. Comprehensive Gynecology. 6th ed. Philadelphia, Pa.: Mosby Elsevier; 2012. http://www.clinicalkey.com. Accessed Sept. 24, 2013.
- Luke B, et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome. Fertility and Sterility. 2010;94:1399.
- Adams JG. Emergency Medicine: Clinical Essentials. 2nd ed. Philadelphia, Pa. Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed Sept. 24, 2013.
- Insler V, et al. Prevention of ovarian hyperstimulation syndrome. http://www.uptodate.com/home. Accessed Sept. 23, 2013.
- Practice Committee of the American Society for Reproductive Medicine. Ovarian hyperstimulation syndrome. Fertility and Sterility. 2006;86:S178.
- Coddington CC (expert opinion). Mayo Clinic, Rochester, Minn. Oct. 2, 2013.
- Rollene NL, et al. Treatment of ovarian hyperstimulation syndrome using a dopamine agonist and gonadotropin releasing hormone antagonist: A case series. Fertility and Sterility. 2009;92:1169.e15.
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