The strongest risk factors for MCI are:

  • Increasing age
  • Having a specific form of a gene known as APOE-e4, also linked to Alzheimer's disease — though having the gene doesn't guarantee that you'll experience cognitive decline

Other medical conditions and lifestyle factors have been linked to an increased risk of cognitive change, but the evidence for these risk factors is less clear. These risk factors include:

  • Diabetes
  • Current smoking
  • Depression
  • High blood pressure
  • Elevated cholesterol
  • Lack of physical exercise
  • Infrequent participation in mentally or socially stimulating activities
Aug. 21, 2012

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