The cause of Meniere's disease isn't well understood. It appears to be the result of the abnormal volume or composition of fluid in the inner ear.
The inner ear is a cluster of connected passages and cavities called a labyrinth. The outside of the inner ear is made of bone (bony labyrinth). Inside is a soft structure of membrane (membranous labyrinth) that's a slightly smaller, similarly shaped version of the bony labyrinth. The membranous labyrinth contains a fluid (endolymph) and is lined with hair-like sensors that respond to movement of the fluid.
In order for all of the sensors in the inner ear to function properly, the fluid needs to retain a certain volume, pressure and chemical composition. Factors that alter the properties of inner ear fluid may help cause Meniere's disease. Scientists have proposed a number of potential causes or triggers, including:
- Improper fluid drainage, perhaps because of a blockage or anatomic abnormality
- Abnormal immune response
- Viral infection
- Genetic predisposition
- Head trauma
Because no single cause has been identified, it's likely that Meniere's disease is caused by a combination of factors.
Dec. 11, 2012
- Flint PW, et al. Cummings Otolaryngology: Head & Neck Surgery. 5th ed. Philadelphia, Pa.: Mosby Elsevier; 2010. http://www.mdconsult.com/books/about.do?about=true&eid=4-u1.0-B978-0-323-05283-2..X0001-8--TOP&isbn=978-0-323-05283-2&uniqId=230100505-57. Accessed Aug. 31, 2012.
- Meniere's disease. Vestibular DisordersAssociation. http://vestibular.org/menieres-disease. Accessed Aug. 31, 2012.
- Dinces EA, et al. Meniere disease. http://www.uptodate.com/index. Accessed Aug. 30, 2012.
- Lalwani AK. Current Diagnosis & Treatment in Otolaryngology — Head & Neck Surgery. 3rd ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=39. Accessed Aug. 29, 2012.
- Rauch SD. Clinical hints and precipitating factors in patients suffering from Meniere's disease. Otolaryngologic Clinics of North America. 2010;43:1011.
- Heart attack, stroke and cardiac arrest warning signs. American Heart Association. http://www.heart.org/HEARTORG/General/Heart-Attack-Stroke-and-Cardiac-Arrest-Signs_UCM_303977_SubHomePage.jsp. Accessed Aug. 31, 2012.
- Meniere's disease. American Academy of Otolaryngology — Head and Neck Surgery. http://www.entnet.org/HealthInformation/menieresDisease.cfm. Accessed Aug. 31, 2012.
- Meniere's disease. National Institute on Deafness and Other Communication Disorders. http://www.nidcd.nih.gov/health/balance/pages/meniere.aspx. Accessed Aug. 31, 2012.
- Potassium. American Cancer Society. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/potassium. Accessed Aug. 31, 2012.
- Sodium (salt or sodium chloride). American Heart Association. http://www.heart.org/HEARTORG/GettingHealthy/NutritionCenter/HealthyDietGoals/Sodium-Salt-or-Sodium-Chloride_UCM_303290_Article.jsp. Accessed Aug. 31, 2012.
- Neff BA (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 18, 2012.
- Neff BA, et al. Auditory and vestibular symptoms and chronic subjective dizziness in patients with Meniere's disease, vestibular migraine, and Meniere's disease with concomitant vestibular migraine. Otology & Neurotology. 2012;33:1235.