Lynch syndrome is an inherited condition that increases your risk of colon cancer and other cancers. Lynch syndrome has historically been known as hereditary nonpolyposis colorectal cancer (HNPCC).
A number of inherited syndromes can increase your risk of colon cancer, but Lynch syndrome is the most common. Doctors estimate that about 3 out of every 100 colon cancers are caused by Lynch syndrome.
Families that have Lynch syndrome usually have more cases of colon cancer than would typically be expected. Lynch syndrome also causes colon cancer to occur at an earlier age than it might in the general population.
March 13, 2015
- Genetics of colorectal cancer (PDQ). National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/genetics/colorectal/healthprofessional. Accessed Feb. 17, 2015.
- Lindor NM, et al. Concise handbook of familial cancer susceptibility syndromes. Journal of the National Cancer Institute Monographs. 2008;38:1.
- Genetic/familial high-risk assessment: Colorectal. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Feb. 17, 2015.
- Lindor NM, et al. Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: A systematic review. Journal of the American Medical Association. 2006;296:1507.
- Giardiello FM, et al. Guidelines on genetic evaluation and management of Lynch syndrome: A consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2014;147:502.
- Syngal S, et al. ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. American Journal of Gastroenterology. 2015;110:223.
- AskMayoExpert. Lynch syndrome. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Making sense of your genes: A guide to genetic counseling. Genetic Alliance. http://www.geneticalliance.org/publications/guidetogeneticcounseling. Accessed Feb. 17, 2015.
- Lynch HT, et al. Milestones of Lynch syndrome: 1895-2015. Nature Reviews Cancer. http://www.nature.com/nrc/journal/vaop/ncurrent/abs/nrc3878.html. Accessed Feb. 17, 2015.
- Thibodeau SN, et al. Microsatellite instability in cancer of the proximal colon. Science. 1993;260:816.
- Vasen HF, et al. Revised guidelines for the clinical management of Lynch syndrome (HNPCC): Recommendations by a group of European experts. Gut. 2013; 62:812.
- Burn J, et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial. The Lancet. 2011;378:2081.
- Lindor NM. Lynch syndrome 101 (years, that is). American Society of Clinical Oncology. http://meetinglibrary.asco.org/content/114000027-144. Accessed Feb. 20, 2015.
- Lindor NM (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. Feb. 19, 2015.
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