Research

Researchers at Mayo Clinic conduct clinical and laboratory research in genetics, causes, new diagnostic tests and treatments for long QT syndrome. Doctors also conduct research in identifying those at risk of sudden death in long QT syndrome and genetic testing for long QT syndrome. Staff in the Windland Smith Rice Sudden Death Genomics Laboratory study long QT syndrome and other causes of sudden cardiac death.

Mayo's research team has studied the genetics of long QT syndrome extensively. Recent investigations include such topics as studying the linking of genetic variation in calcium-handling proteins to long QT syndrome, and studying two new syndromes — triadin knockout syndrome (TKOS) and arrhythmic bileaflet mitral valve prolapse syndrome.

Read more about research in the Windland Smith Rice Sudden Death Genomics Laboratory and in the Cardiovascular Research Center.

Publications

See a list of publications by Mayo authors on PubMed, a service of the National Library of Medicine.

Research Profiles

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July 22, 2017
References
  1. What is long QT syndrome? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/qt. Accessed Feb. 18, 2017.
  2. Conduction disorders. American Heart Association. http://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/Conduction-Disorders_UCM_302046_Article.jsp#.WLhwehiZOu4. Accessed March 2, 2017.
  3. Seslar SP, et al. Clinical features of congenital long QT syndrome. http://www.uptodate.com/home. Accessed Feb. 15, 2017.
  4. Zimetbaum PJ, et al. Genetics of congenital and acquired long QT syndrome. http://www.uptodate.com/home. Accessed Feb. 15, 2017.
  5. Berul CI, et al. Acquired long QT syndrome. http://www.uptodate.com/home. Accessed Feb. 15, 2017.
  6. AskMayoExpert. Screening (adult). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017.
  7. AskMayoExpert. Significance of a long QT interval (adult). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017.
  8. What is the heart? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/hhw. Accessed Feb. 18, 2017.
  9. AskMayoExpert. Prolonged QT interval: Signs and symptoms (adult). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017.
  10. Arrhythmia. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/arr/types. Accessed Feb. 18, 2017.
  11. Seslar SP, et al. Diagnosis of congenital long QT syndrome. http://www.uptodate.com/home. Accessed Feb. 18, 2017.
  12. Ferri FF. Prolonged Q-T interval syndrome. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed Feb. 15, 2017.
  13. Zimetbaum PJ, et al. Prognosis and management of congenital long QT syndrome. http://www.uptodate.com/home. Accessed Feb. 15, 2017.
  14. Ackerman JP, et al. The promise and peril of precision medicine: Phenotyping still matters most. Mayo Clinic Proceedings. 2016;91:1606.
  15. Aziz PF, et al. Sports participation in genotype positive children with long QT syndrome. Clinical Electrophysiology. 2015;1:62.
  16. Riggin ER. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Jan. 10, 2017.
  17. Schwartz PJ, et al. Management of survivors of cardiac arrest — The importance of genetic investigation. Nature Reviews: Cardiology. 2016;13:560.
  18. Genetic testing. Sudden Arrhythmia Death Syndromes Foundation. http://www.sads.org/living-with-sads/Insurance/Genetic-Testing#.VfB_G9iFODZ. Accessed Feb. 15, 2017.
  19. Mazzanti A, et al. Gene-specific therapy with mexiletine reduces arrhythmic events in patients with long QT syndrome type 3. Journal of the American College of Cardiology. 2016;67:1053.
  20. Fish Oil. Natural Medicines. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=993. Accessed Feb. 21, 2017.
  21. Schwartz PJ, et al. Predicting the unpredictable: Drug-induced QT prolongation and torsades de pointes. Journal of the American College of Cardiology. 2016;67:1639.
  22. Loar RW, et al. Sudden cardiac arrest during sex in patients with either catecholaminergic polymorphic ventricular tachycardia or long-QT syndrome: A rare but shocking experience. Journal of Cardiovascular Electrophysiology. 2015;26:300.
  23. Garg L, et al. The influence of pregnancy in patients with congenital long QT syndrome. Cardiology in Review. In press. Accessed Feb. 20, 2017.
  24. Ackerman MJ (expert opinion). Mayo Clinic, Rochester, Minn. Mar. 13, 2017.
  25. Priori SG, et al. HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes. Heart Rhythm. 2013;10:1932.
  26. Priori SG, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. European Heart Journal. 2015;36:2793.
  27. Ackerman MJ, et al. Beta-blocker therapy for long QT syndrome and catecholaminergic polymorphic ventricular tachycardia: Are all beta-blockers equivalent? Heart Rhythm. 2017;14:e41.
  28. Fernández-Falgueras A, et al. Cardiac channelopathies and sudden death: Recent clinical and genetic advances. Biology. 2017;6:7.
  29. Giudicessi JR, et al. Calcium revisited: New insights into the molecular basis of long-QT syndrome. Circulation: Arrhythmia and Electrophysiology. 2016;9:e002480.
  30. Collura CA, et al. Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery. Heart Rhythm. 2009;6:752.
  31. Gaba P, et al. Implantable cardioverter-defibrillator explantation for overdiagnosed or overtreated congenital long QT syndrome. Heart Rhythm. 2016;13:879.
  32. Desimone CV, et al. Effects on repolarization using dynamic QT interval monitoring in long-QT patients following left cardiac sympathetic denervation. Journal of Cardiovascular Electrophysiology. 2015;26:434.
  33. Johnson JN, et al. Competitive sports participation in athletes with congenital long QT syndrome. JAMA. 2012;308:765.
  34. Johnson JN, et al. Return to play? Athletes with congenital long QT syndrome. British Journal of Sports Medicine. 2013;47:28.
  35. Antiel RM, et al. Quality of life after videoscopic left cardiac sympathetic denervation in patients with potentially life-threatening cardiac channelopathies/cardiomyopathies. Heart Rhythm. 2016;13:62.
  36. Sriram CS, et al. Malignant bileaflet mitral valve prolapse syndrome in patients with otherwise idiopathic out-of-hospital cardiac arrest. Journal of the American College of Cardiology. 2013;62:222.

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