The cause of lichen planus is unknown, though strong evidence suggests that inflammation, controlled by the immune system, gives rise to the lesions. However, certain diseases, medical conditions or other factors may act as triggers of lichen planus in some people.

The possible triggers of lichen planus include:

  • Hepatitis C infection
  • Hepatitis B vaccine
  • Flu vaccine
  • Certain pigments, chemicals and metals
  • Nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil, Motrin IB, others) and naproxen (Aleve, others)
  • Certain medications for heart disease, high blood pressure or arthritis
Feb. 22, 2013

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