Complications of hyperparathyroidism are primarily related to the long-term effect of too little calcium in your bones and too much calcium circulating in your bloodstream. Common complications include:
May 28, 2014
- Osteoporosis. The loss of calcium often results weak, brittle bones that fracture easily (osteoporosis).
- Kidney stones. The excess of calcium in your blood may lead to excess calcium in your urine, which can cause small, hard deposits of calcium and other substances to form in your kidneys. A kidney stone usually causes significant pain as it passes through the urinary tract.
- Cardiovascular disease. Although the exact cause-and-effect link is unclear, high calcium levels are associated with cardiovascular conditions, such as high blood pressure (hypertension) and certain types of heart disease.
- Neonatal hypoparathyroidism. Severe, untreated hyperparathyroidism in pregnant women may cause dangerously low levels of calcium in newborns.
- Primary hyperparathyroidism. National Endocrine and Metabolic Diseases Information Service. http://endocrine.niddk.nih.gov/pubs/hyper/. Accessed Feb. 15, 2014.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed Feb. 15, 2014.
- El-Hajj Fuleihan G. Pathogenesis and etiology of primary hyperthyroidism. http://www.uptodate.com/home. Accessed Feb. 15, 2014.
- Papadakis MA, et al. Current Medical Diagnosis & Treatment 2014. 53rd ed. New York, N.Y.: The McGraw-Hill Companies; 2014. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=1. Accessed Feb. 15, 2014.
- Bilezikian JP, et al. Guidelines for the management of asymptomatic primary hyperparathyroidism: Summary statement from the third international workshop. Journal of Clinical Endocrinology and Metabolism. 2009;94:335.
- Hormone replacement therapy. Micromedex 2.0 Healthcare Series. http://www.micromedexsolutions.com. Accessed Feb. 15, 2014.
- Vitamin D: Fact sheet for consumers. Office of Dietary Supplements. http://ods.od.nih.gov/factsheets/VitaminD-QuickFacts. Accessed Feb. 15, 2014.
- Calcium: Fact sheet for consumers. Office of Dietary Supplements. http://ods.od.nih.gov/factsheets/Calcium-QuickFacts. Accessed Feb. 15, 2014.
- Smoking and bone health. NIH Osteoporosis and Related Bone Diseases — National Resource Center. http://www.niams.nih.gov/Health_Info/Bone/Osteoporosis/Conditions_Behaviors/bone_smoking.asp. Accessed Feb. 15, 2014.
- Korkmaz HA, et al. Neonatal seizure as a manifestation of unrecognized maternal hyperparathyroidism. Journal of Clinical Research in Pediatric Endocrinology. 2013;5:206.
- Nippoldt TB (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 28, 2014.
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