Hemolytic uremic syndrome (HUS) is a condition that results from the abnormal premature destruction of red blood cells. Once this process begins, the damaged red blood cells start to clog the filtering system in the kidneys, which may eventually cause the life-threatening kidney failure associated with hemolytic uremic syndrome.
Most cases of hemolytic uremic syndrome develop in children after two to 14 days of diarrhea — often bloody — due to infection with a certain strain of Escherichia coli (E. coli). Adults also may develop hemolytic uremic syndrome after an E. coli infection, but the cause also may be certain medications, other types of infections, pregnancy or it may be unknown.
Though hemolytic uremic syndrome is a serious condition, getting timely and appropriate treatment leads to a full recovery for most people — especially young children.
Jul. 03, 2013
- Niaudet P. Clinical manifestations and diagnosis of Shiga toxin associated (typical) hemolytic uremic syndrome in children. http://www.uptodate.com/home. Accessed May 26, 2013.
- Tintinalli JE, et al. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. 7th ed. New York, N.Y.: The McGraw-Hill Companies; 2011. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=40. Accessed May 26, 2013.
- Bavaro MF. E. coli O157:H7 and other toxigenic strains: The curse of global food distribution. Current Gastroenterology Reports. 2012;14:317.
- Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec11/ch133/ch133g.html. Accessed May 26, 2013.
- Hemolytic uremic syndrome in children. National Kidney and Urologic Diseases Information Clearinghouse . http://kidney.niddk.nih.gov/KUDiseases/pubs/childkidneydiseases/hemolytic_uremic_syndrome/. Accessed May 21, 2013.
- Bielaszewska M, et al. Enterohemorrhagic escherichia coli O26:H11/H-: A new virulent clone emerges in Europe. Clinical Infectious Diseases. 2013;56:1373.
- George JN. Causes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in adults. http://www.uptodate.com/home. Accessed May 26, 2013.
- Elliott MM, et al. Interventions for haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura. Cochrane Database of Systematic Reviews. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003595.pub2/abstract. Accessed May 26, 2013.
- Food safety. Centers for Disease Control and Prevention. http://www.cdc.gov/foodsafety/facts.html. Accessed May 26, 2013.
- Niaudet P. Treatment and prognosis of Shiga toxin associated (typical) hemolytic uremic syndrome in children. http://www.uptodate.com/home. Accessed May 26, 2013.
- Niaudet P. Atypical hemolytic uremic syndrome in children. http://www.uptodate.com/home. Accessed May 26, 2013.
- Nester CM, et al. Atypical hemolytic uremic syndrome: What is it, how is it diagnosed, and how is it treated? Hematology. 2012;2012:617.
- Ground beef and food safety. U.S. Department of Agriculture. http://www.fsis.usda.gov/factsheets/ground_beef_and_food_safety/. Accessed May 28, 2013.
- Hunt JM. Shiga toxin-producing Escherichia coli (STEC). Clinics in Laboratory Medicine. 2010;30:21.