Risk factorsBy Mayo Clinic Staff
Hand-foot-and-mouth disease primarily affects children younger than age 10, often those under 5 years. Children in child care centers are especially susceptible to outbreaks of hand-foot-and-mouth disease because the infection spreads by person-to-person contact, and young children are the most susceptible.
Children usually develop immunity to hand-foot-and-mouth disease as they get older by building antibodies after exposure to the virus that causes the disease. However, it's possible for adolescents and adults to get the disease.
Aug. 22, 2014
- Modlin JF. Clinical manifestations and diagnosis of enterovirus and parechovirus infections. http://www.uptodate.com/home. Accessed June 28, 2014.
- Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=4. Accessed June 28, 2014.
- Hand, foot, and mouth disease. Centers for Disease Control and Prevention. http://www.cdc.gov/hand-foot-mouth/about/index.html. Accessed June 21, 2014.
- Hand, foot, and mouth disease information sheet. World Health Organization. http://www.wpro.who.int/emerging_diseases/hfmd.information.sheet/en/#. Accessed June 29, 2014.
- Suzuki Y, et al. Risk factors for severe hand foot and mouth disease. Pediatrics International. 2010;52:203.
- Modlin JF. Epidemiology, pathogenesis, treatment, and prevention of enterovirus and parechovirus infections. http://www.uptodate.com/home. Accessed June 28, 2014.