SymptomsBy Mayo Clinic Staff
Common signs and symptoms of Graves' disease include:
- Anxiety and irritability
- A fine tremor of your hands or fingers
- Heat sensitivity and an increase in perspiration or warm, moist skin
- Weight loss, despite normal eating habits
- Enlargement of your thyroid gland (goiter)
- Change in menstrual cycles
- Erectile dysfunction or reduced libido
- Frequent bowel movements
- Bulging eyes (Graves' ophthalmopathy)
- Thick, red skin usually on the shins or tops of the feet (Graves' dermopathy)
- Rapid or irregular heartbeat (palpitations)
About 30 percent of people with Graves' disease show some signs and symptoms of a condition known as Graves' ophthalmopathy. In Graves' ophthalmopathy, inflammation and other immune system events affect muscles and other tissues around your eyes. The resulting signs and symptoms may include:
- Bulging eyes (exophthalmos)
- Gritty sensation in the eyes
- Pressure or pain in the eyes
- Puffy or retracted eyelids
- Reddened or inflamed eyes
- Light sensitivity
- Double vision
- Vision loss
An uncommon manifestation of Graves' disease, called Graves' dermopathy, is the reddening and thickening of the skin, most often on your shins or the tops of your feet.
When to see a doctor
A number of medical conditions can cause the signs and symptoms associated with Graves' disease. See your doctor if you experience any potential Graves-related problems to get a prompt and accurate diagnosis.
Seek emergency care if you're experiencing heart-related signs and symptoms, such as a rapid or irregular heartbeat, or if you develop vision loss.
July 01, 2014
- Bartalena L. Diagnosis and management of Graves disease: A global overview. Nature Reviews Endocrinology. 2013;9:724.
- Graves' disease. U.S. Department of Health and Human Services. http://www.endocrine.niddk.nih.gov/pubs/graves/index.aspx. Accessed March 9, 2014.
- Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=4. Accessed March 9, 2014.
- Papadakis MA, ed., et al. Current Medical Diagnosis & Treatment 2014. 53rd ed. New York, N.Y.: The McGraw-Hill Companies; 2014. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=1. Accessed March 9, 2014.
- Falgarone G, et al. Role of emotional stress in the pathophysiology of Graves' disease. European Journal of Endocrinology. 2013;168:R13.
- Ross DS. Treatment of Graves' hyperthyroidism. http://www.uptodate.com/home. Accessed March 9, 2014.
- Genovese BM, et al. What is the best definitive treatment for Graves' disease? A systematic review of the existing literature. Annals of Surgical Oncology. 2013;20:660.
- Mayo CH. The surgical treatment of goiter. The Journal of the American Medical Association. 1904;XLII:1059.
- Riggin EA. Decision Support System. Mayo Clinic, Rochester, Minn. March 3, 2014.