For more than 30 years, the Mayo Clinic Department of Ophthalmology has conducted research related to Fuchs' dystrophy and cornea transplantation. A Mayo Clinic eye doctor and researcher helped develop an advanced clinical specular microscopy technique, which allows corneal endothelial cells in the normal, diseased and transplanted cornea to be imaged and evaluated. It's a crucial resource today for understanding cornea and cornea transplant function.
Mayo Clinic researchers are assessing outcomes of new cornea transplant techniques for people with corneal swelling from diseases such as Fuchs' dystrophy. Prospective studies assessing the changes that are smaller than those which can be seen with the ordinary light microscope (ultrastructural corneal changes) in Fuchs' dystrophy also are in progress.
In addition, researchers at Mayo Clinic recently identified the first genetic link (association) for the common form of Fuchs' dystrophy. Researchers are conducting lab studies to determine the underlying causes of Fuchs' dystrophy and the factors involved in disease progression.Read more about cornea research at Mayo Clinic.
See a list of publications by Mayo Clinic doctors on Fuchs' dystrophy on PubMed, a service of the National Library of Medicine.
Jul. 16, 2011
- Facts about the cornea and corneal disease. National Eye Institute. http://www.nei.nih.gov/health/cornealdisease. Accessed May 31, 2011.
- Clintworth GK. Corneal dystrophies. Orphanet Journal of Rare Diseases. 2009;4:7.
- Borboli S, et al. Mechanisms of disease: Fuchs' endothelial dystrophy. Ophthalmology Clinics of North America. 2002;15:17.
- Corneal conditions. Cornea Research Foundation of America. http://www.cornea.org/index.php/research/corneal_conditions. Accessed May 31, 2011.
- Afshari NA, et al. Clinical study of Fuchs corneal endothelial dystrophy leading to penetrating keratoplasty. Archives of Ophthalmology. 2006;124:777.
- Visiting your doctor. The Corneal Dystrophy Foundation. http://www.cornealdystrophyfoundation.org/cdfliterature/Visiting_Your_Doctor.pdf. Accessed May 31, 2011.
- Hecker LA, et al. Anterior keratocyte depletion in Fuchs endothelial dystrophy. Archives of Ophthalmology. 2011;129:555.