Epidermolysis bullosa complications include:
Aug. 22, 2014
- Infection. Blistering skin is vulnerable to bacterial infection.
- Sepsis. Sepsis occurs when bacteria from a massive infection enter your bloodstream and spread throughout your body. Sepsis is a rapidly progressing, life-threatening condition that can cause shock and organ failure.
- Deformities. Severe forms of epidermolysis bullosa can cause fusion of fingers or toes and abnormal bending of joints (contractures), such as those of the fingers, knees and elbows.
- Malnutrition and anemia. Blisters in the mouth can make eating difficult and lead to malnutrition. This may lead to anemia (such as low iron levels in the blood), delayed wound healing or, in children, slowed growth.
- Dehydration. Large, open blisters can cause loss of body fluid that leads to severe dehydration.
- Constipation. Difficulty passing stool may be due to painful blisters in the anal area. It can also be caused by not ingesting enough liquids or high-fiber foods, such as fruits and vegetables.
- Eye disorders. Inflammation of the eye can harm the clear covering over the eye (cornea) and, sometimes, cause blindness.
- Skin cancer. Adolescents and adults with certain types of epidermolysis bullosa are at high risk of developing a type of skin cancer known as squamous cell carcinoma.
- Death. Infants with a severe form of junctional epidermolysis bullosa are at high risk of infections and loss of body fluids from widespread blistering. Their survival also may be threatened because of blistering, which may hamper their ability to eat and breathe. Many of these infants die in childhood.
- Fine JD, et al. Inherited epidermolysis bullosa: Updated recommendations on diagnosis and classification. Journal of the American Academy of Dermatology. In press. Accessed April 9, 2014.
- Pickert A, et al. Immunodermatology and blistering disorders. Journal of American Academy of Dermatology. 2013;68:AB110.
- Pride HB, et al. What's new in pediatric dermatology? Part 1. Diagnosis and pathogenesis. Journal of the American Academy of Dermatology. 2013;68:885.e2.
- Brick K, et al. Epidermolysis bullosa pruriginosa: Further clarification of the phenotype. Pediatric Dermatology. 2012;29:732.
- Lehman JS, et al. Epidermolysis bullosa acquisita: Concise review and practical considerations. International Journal of Dermatology. 2009;48:227.
- Epidermolysis bullosa. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Epidermolysis_Bullosa/. Accessed April 10, 2014.
- About EB. Dystrophic Epidermolysis Bullosa Research Association of America. http://www.debra.org/abouteb. Accessed April 10, 2014.
- AskMayoExpert. Pemphigoid. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Lebwohl MG. Treatment of Skin Disease. 4th ed. Philadelphia, Pa.: Elsevier Saunders; 2014. http://www.clinicalkey.com. Accessed April 10, 2014.
- Pope E, et al. A consensus approach to wound care in epidermolysis bullosa. Journal of the American Academy of Dermatology. 2010;67:904.
- Gonzalez ME. Evaluation and treatment of the newborn with epidermolysis bullosa. Seminars in Perinatology. 2013;37:32.
- Lakdawala N, et al. The role of nutrition in dermatologic diseases: Facts and controversies. Clinics in Dermatology. 2013;31:677.
- Jurj G, et al. Epidermolysis bullosa: Report of three cases treated with homeopathy. Homeopathy. 2011;100:264.
- Healthcare problems. Dystrophic Epidermolysis Bullosa Research Association. http://www.debra.org/healthcare. Accessed June 10, 2011. Accessed April 10, 2014.
- Hand JL (expert opinion). Mayo Clinic, Rochester, Minn. May 8, 2014.
You Are ... The Campaign for Mayo Clinic
Mayo Clinic is a not-for-profit organization. Make a difference today.