Mayo Clinic researchers have made a number of important contributions to studies on depression, especially in relation to other medical problems, psychiatric disorders or addictions. Areas of research include:

  • How genomic variations may predict response to medications (pharmacogenomics)
  • Developing neuroimaging methods to assess variation and abnormalities in brain function of people with mood disorders
  • Electroconvulsive therapy for mood disorders
  • Transcranial magnetic stimulation for mood disorders
  • Genetic and environmental factors in depression
  • Effectiveness of deep brain stimulation in treatment-resistant depression

Mayo scientists sometimes use a blood test, the cytochrome P450 test, to help pinpoint genetic factors that play a role in a person's response to most antidepressant medications. This information helps doctors understand which medications might be better tolerated for one person versus another and which should be avoided based on how a person's body breaks down (metabolizes) drugs.

Read more about research in the Department of Psychiatry and Psychology at Mayo Clinic.


See a list of publications on depression by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

April 17, 2015