Drug-eluting stents: Do they increase heart attack risk?

Drug-eluting stents, once thought to increase heart attack risk, are generally considered safe if used properly.

By Mayo Clinic Staff

Stents are small mesh tubes inserted to keep arteries open after a procedure called angioplasty (percutaneous coronary intervention, or PCI). Drug-eluting stents have a polymer coating over mesh that emits a drug over time to help keep the blockage from recurring.

In general, drug-eluting stents are preferred over bare-metal stents for most people. Not only are they more likely to keep the blockage from recurring than are bare-metal stents, but studies show the latest drug-eluting stents to be at least as safe as bare-metal stents.

Drug-eluting stents, however, require longer treatment with blood thinners to prevent sudden stent closure from clotting. This makes them less desirable for people with bleeding problems or those who'll need some type of surgery within a year after the stent is put in. Here's information to help you talk to your doctor about whether a drug-eluting stent is right for you.

What's a stent?

Stents are usually metal mesh tubes inserted during PCI, a procedure that widens the blocked artery by temporarily inserting and inflating a tiny balloon. Stents help prevent the artery from becoming blocked again (restenosis).

Even with stents, 10 to 20 percent of arteries become blocked again. Drug-eluting stents drop the recurrence rate further.

Stents can be classified into two categories: bare-metal stents and drug-eluting stents.

  • Bare-metal stents have no special coating. They act as scaffolding to prop open blood vessels after they're widened with angioplasty. As the artery heals, tissue grows around the stent, holding it in place. However, sometimes an overgrowth of scar tissue in the arterial lining increases the risk of reblockage.
  • Drug-eluting stents are coated with medication that is slowly released (eluted) to help prevent the growth of scar tissue in the artery lining. This helps the artery remain smooth and open, ensuring good blood flow.

Many people with heart problems have been successfully treated with drug-eluting stents, preventing the need for more-invasive procedures, such as coronary artery bypass surgery. The reduced risk of reblocked arteries from drug-eluting stents reduces the need for repeat angioplasty procedures, which carry the risk of complications such as heart attack and stroke.

What are your options for treating clogged heart arteries?

Drug-eluting stents are just one option for treating narrowed heart arteries. You basically have four options if your arteries become narrowed, each with risks:

  • Medications and lifestyle changes. If you have symptoms from your narrowed coronary arteries, such as angina, and your condition isn't severe or immediately life-threatening, it may be worth first trying medications, such as beta blockers, nitrates, calcium channel blockers, aspirin and statins.

    With medications, lifestyle changes, such as stopping smoking, eating a more heart-healthy diet and exercising, can be as effective as receiving a stent in some circumstances. Even if you receive a stent, your doctor will likely also prescribe medications, such as statins, and lifestyle changes.

  • Bare-metal stents. These stents can work well, but have a higher rate of restenosis than do drug-eluting stents. If you'll need surgery that's not heart-related (for example, a stomach or hernia operation) soon after your stent placement, or if you have a bleeding disorder, you may do better with a bare-metal stent.
  • Drug-eluting stents. Drug-eluting stents are safe and effective in most circumstances, and have a lower rate of restenosis than do bare-metal stents. For optimum effectiveness, you must take your medications as prescribed.
  • Coronary bypass surgery. Bypass surgery is used to divert blood around blocked arteries in the heart. The surgeon takes a healthy blood vessel from your leg, arm or chest and connects it to the other arteries in your heart so that blood is bypassed around the diseased or blocked area.

    Bypass surgery works well, but it's more invasive than using stents, which means a longer recovery time and greater risk of complications than with stents.

May 30, 2014