Treatments and drugs

By Mayo Clinic Staff

There is no cure for cold urticaria, but treatment can help. Treatment includes avoiding cold temperatures and exposure to sudden changes in temperature. Medications can help prevent and reduce symptoms.

Medications used to treat cold urticaria include:

  • Antihistamines. These medications block the symptom-producing release of histamine. Some of these medications are available over-the-counter, whereas others require a prescription. Examples include loratadine (Claritin), fexofenadine (Allegra), cetirizine (Zyrtec), levocetirizine (Xyzal) and desloratadine (Clarinex).
  • Cyproheptadine. This medication is an antihistamine that also affects nerve impulses that lead to symptoms.
  • Doxepin (Silenor). Normally used to treat anxiety and depression, this medication can also reduce cold urticaria symptoms.

These medications won't cure cold urticaria — they'll only ease symptoms. If you have cold urticaria because of an underlying health problem, you may need medications or other treatment for that condition as well.

Nov. 15, 2011