Headaches and hormones: What's the connection?

Being female has some real health advantages, but not when it comes to headaches — particularly migraines. Fortunately, there's help. By Mayo Clinic Staff

Many factors contribute to headaches for both men and women, including family history and age. Women, however, often notice a relationship between headaches and hormonal changes.

The hormones estrogen (ES-truh-jen) and progesterone (pro-JES-tuh-rohn) — which play key roles in regulating the menstrual cycle and pregnancy — may affect headache-related chemicals in the brain. Steady estrogen levels may improve headaches, while estrogen levels that lower or change can make headaches worse.

Though fluctuating hormone levels can influence headache patterns, you're not completely at the mercy of your hormones. Your doctor can help you treat — or prevent — headaches.

During menstruation

The drop in estrogen just before your period may contribute to headaches. Many women with migraines report headaches before or during menstruation.

Your menstrual-related migraines may be treated in several ways, including:

  • Apply ice. Hold a cold cloth or an ice pack to the painful area on your head or neck. Wrap the ice pack in a towel to protect your skin.
  • Relaxation exercises. Try relaxation exercises to lower stress.
  • Biofeedback. Biofeedback may improve your headaches by helping you to monitor how your body responds to stress.
  • Acupuncture. Acupuncture may improve your headaches and help you relax.
  • Take over-the-counter pain relievers. Your doctor may recommend you take nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen (Aleve) or ibuprofen (Advil, Motrin IB, others). These medications may relieve your pain soon after your headache begins.
  • Take triptans. Your doctor may prescribe triptans, medications that block pain signals in your brain. Triptans often may relieve pain from your headache within two hours and help to control vomiting.
  • Take pain relievers and triptans. Some women may take a combination of NSAIDs and triptans to relieve pain from menstrual migraines.
  • Take other prescription pain medications. Sometimes your doctor may suggest other prescription pain medications, such as dihydroergotamine (Dihydroergotamine Mesylate).

Preventive treatment

If you have several debilitating headaches a month, your doctor may recommend preventive treatment with NSAIDs or triptans.

If your menstrual cycle is regular, it's often most effective to take preventive headache medication starting a few days before your period and continuing through up to two weeks after the start of your period.

If you have migraines throughout your menstrual cycle or you have irregular periods, your doctor may recommend that you take preventive medications every day.

Daily medications may include beta blockers, anticonvulsants, calcium channel blockers, antidepressants or magnesium. Doctors will review any other medical conditions you may have to determine which medications may be most appropriate for you.

Making lifestyle changes, such as reducing stress and exercising regularly, also may help reduce the frequency, length and severity of migraines.

Using birth control pills

Some women first experience migraines while taking birth control pills. Hormonal birth control may change existing headache patterns — sometimes for the better, sometimes for the worse or sometimes not at all.

If you experience migraines while taking birth control pills, consult your doctor. It may help to:

  • Use a monthly pill pack with fewer inactive (placebo) days.
  • Eliminate the placebo days completely from most months by taking extended-cycle estrogen-progestin birth control pills (Seasonale, Seasonique, others).
  • Use birth control pills that have a lower dose of estrogen to reduce the drop in estrogen during the placebo days.
  • Take NSAIDs and triptans during the placebo days.
  • Take a low dose of estrogen pills or wear an estrogen patch during the placebo days.
  • Use an estrogen-containing skin patch for one day, once a week, during the placebo days if you're using a birth control patch.
  • Take a progestin-only birth control pill (Micronor, others) as an alternative to oral estrogen-progestin birth control pills, if you're not able to take estrogen-progestin birth control pills due to other conditions.

Birth control pills may help reduce the frequency and severity of menstrual-related migraines. Using birth control pills to prevent menstrual-related migraines may be appropriate for some women who haven't been helped by other methods.

Nov. 13, 2012 See more In-depth