Overview

Charcot (shahr-KOH)-Marie-Tooth disease is a group of inherited disorders that cause nerve damage. This damage is mostly in your arms and legs (peripheral nerves). Charcot-Marie-Tooth is also called hereditary motor and sensory neuropathy.

Charcot-Marie-Tooth disease results in smaller, weaker muscles. You may also experience loss of sensation and muscle contractions, and difficulty walking. Foot deformities such as hammertoes and high arches are also common. Symptoms usually begin in your feet and legs, but they may eventually affect your hands and arms.

Symptoms of Charcot-Marie-Tooth disease typically appear in adolescence or early adulthood, but may also develop in midlife.

March 31, 2016
References
  1. Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/charcot_marie_tooth/detail_charcot_marie_tooth.htm. Accessed Dec. 3, 2015.
  2. Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. http://www.mda.org/publications/facts-about-charcot-marie-tooth-related-diseases. Accessed Dec. 3, 2015.
  3. Aminoff MJ, et al. Sensory disorders. In: Clinical Neurology. 8th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com. Accessed Dec. 3, 2015.
  4. Cruse RP. Hereditary primary motor sensory neuropathies, including Charcot-Marie-Tooth disease. http://www.uptodate.com/home. Accessed Dec. 3, 2015.
  5. Ekins S, et al. A brief review of recent Charcot-Marie-Tooth research and priorities. F1000 Research. 2015;4:53.
  6. Klein C (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 19, 2016.
  7. Verma A. Next-generation sequencing and diagnosis of Charcot-Marie-Tooth Disease disease. Annals of Indian Academy of Neurology. 2014 Oct-Dec; 17(4): 383–386.
  8. Important foot care for people with CMT. Charcot-Marie-Tooth Disease Association. http://www.cmtausa.org/resource-center/treatment-management/foot-care/important-foot-care-for-people-with-cmt/. Accessed Jan. 29, 2016.
  9. Pedicure pointers. American Podiatric Medical Association. http://www.apma.org/Learn/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Jan. 29, 2016.