What cancers may be treated with monoclonal antibody drugs?
Monoclonal antibody treatments have been developed for some but not all cancers, and certain types of cancer cells are more vulnerable than others to monoclonal antibody interventions. Nonetheless, treatments have been approved for a number of cancers, including the following:
- Brain cancer
- Breast cancer
- Chronic lymphocytic leukemia
- Colorectal cancer
- Head and neck cancers
- Hodgkin's lymphoma
- Lung cancer
- Non-Hodgkin's lymphoma
- Prostate cancer
- Stomach cancer
How are monoclonal antibody drugs used in cancer treatment?
Monoclonal antibodies are administered through a vein (intravenously). How often you undergo monoclonal antibody treatment depends on your cancer and the drug you're receiving. Some monoclonal antibody drugs may be used in combination with other treatments, such as chemotherapy or hormone therapy.
Some monoclonal antibody drugs are a part of standard treatment plans. Others are still experimental and used when other treatments have not been successful.
What types of side effects do monoclonal antibody drugs cause?
In general, monoclonal antibody treatment carries fewer side effects than do traditional chemotherapy treatments.
However, monoclonal antibody treatment for cancer may cause side effects, some of which, though rare, can be very serious. Talk to your doctor about what side effects are associated with the particular drug you're receiving.
Common side effects
In general, the more common side effects caused by monoclonal antibody drugs include:
- Allergic reactions, such as hives or itching
- Flu-like signs and symptoms, including chills, fatigue, fever, and muscle aches and pains
- Nausea, vomiting
- Skin rashes
- Low blood pressure
Serious side effects
Serious, but rare, side effects of monoclonal antibody therapy may include:
- Infusion reactions. Severe allergy-like reactions can occur and, in very few cases, lead to death. You may receive medicine to block an allergic reaction before you begin monoclonal antibody treatment. Infusion reactions usually occur while treatment is being administered or soon after, so your health care team will watch you closely for a reaction.
- Low blood cell counts. Monoclonal antibodies that deliver radioactive particles or chemotherapy drugs may be associated with low blood cell counts that can be severe and persistent.
- Heart problems. Certain monoclonal antibodies increase the risk of high blood pressure, congestive heart failure and heart attacks.
- Lung problems. Some monoclonal antibodies are associated with a higher risk of inflammatory lung disease.
- Skin problems. Sores and rashes on your skin can lead to serious infections in some cases. Serious sores can also occur on the tissue that lines your cheeks and gums (mucosa).
- Bleeding. Monoclonal antibody drugs designed to stop cancer from forming new blood vessels have an increased risk of severe internal bleeding.
What should you consider when deciding on monoclonal antibody drug treatment?
Discuss your cancer treatment options with your doctor. Together you can weigh the benefits and risks of each treatment and decide whether a monoclonal antibody treatment is right for you.
Questions to ask your doctor include:
Sept. 09, 2016
- Has my tumor been tested to see if a monoclonal antibody treatment might be of benefit? Simple tests on tumor samples can often tell if the currently available monoclonal antibody treatments might help your specific cancer.
- Has the monoclonal antibody drug shown a clear benefit? Ask your doctor about evidence of the treatment's effect in studies. Did it slow cancer growth? Did it result in reduced tumor sizes? Is this a first line of treatment or a treatment we try when others don't work?
- What are the likely side effects of monoclonal antibody treatment? With your doctor, you can determine whether the potential side effects of treatment are worth the likely benefit.
- How much will monoclonal antibody treatment cost? Monoclonal antibody drugs can cost thousands of dollars for each treatment. Ask your care team to help you determine if the treatment is covered by your insurance.
- Is monoclonal antibody treatment available in a clinical trial? Clinical trials, which are studies of new treatments and new ways to use existing treatments, may be available to you. In a clinical trial, the cost of the monoclonal antibody drug may be paid for as a part of the study. Also, you may be able to try new monoclonal antibody drugs. Talk to your doctor about what clinical trials may be open to you.
See more In-depth
- Biological therapies for cancer. National Cancer Institute. http://www.cancer.gov/about-cancer/treatment/types/immunotherapy/bio-therapies-fact-sheet. Accessed July 11, 2016.
- Cancer immunotherapy. American Cancer Society. http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/immunotherapy/index. Accessed July 11, 2016.
- Weiner GJ. Building better monoclonal antibody-based therapeutics. Nature Reviews Cancer. 2015;15:361. Accessed July 12, 2016.
- Niederhuber JE, et al., eds. Therapeutic antibodies and imunologic conjugates. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed March 31, 2016.
- Guan M, et al. Adverse events of monoclonal antibodies used for cancer therapy. BioMed Research International. 2015;Article ID 428169. http://dx.doi.org/10.1155/2015/428169 Accessed July 11, 2016.
- Weiner ML, et al. Monoclonal antibodies for the treatment of cancer. In: The Molecular Basis of Cancer. Philadelphia, Pa.: Elsevier; 2015. http://www.clincalkey.com. Accessed July 11, 2016.
- Moynihan TJ (medical expert). Mayo Clinic, Rochester, Minn. July 25, 2016.