C. difficile infection care at Mayo Clinic

Mayo Clinic specializes in treating people with difficult cases of C. difficile who haven't responded to standard medical treatments or who have developed complications such as an inflamed colon. The Division of Gastroenterology and Hepatology at Mayo Clinic in Rochester, Minnesota, opened a C. difficile clinic that specializes in treating patients with C. difficile infection.

Your Mayo Clinic care team

Mayo Clinic uses a multidisciplinary team approach to evaluation and management of C. difficile infection with a team consisting of physicians, nurses, study coordinators and laboratory personnel. Doctors who specialize in digestive and infectious diseases work closely with laboratory medicine specialists and scientists specializing in the gut microbiome and individualized medicine to diagnose and treat your condition.

Advanced diagnosis and treatment

Mayo Clinic uses the polymerase chain reaction (PCR) test, the most accurate diagnostic test available to confirm C. difficile infection. The high sensitivity of PCR, together with its rapid turnaround time, allows prompt treatment for people with C. difficile infection, likely reducing opportunity for spreading infection and improving outcomes.

For recurrent or stubborn C. difficile infections, the fecal microbiota transplant (FMT) has been performed at Mayo Clinic with a success rate higher than 90 percent. FMT therapy involves infusing healthy donor stools in people with C. difficile infections. Mayo Clinic performs extensive testing of donors and recipients before performing the procedure and offers the choice of related (family) or standard donors. Because donor testing typically isn't covered by insurance, Mayo Clinic has a standard donor pool to help reduce the cost to potential recipients. Mayo Clinic also participates in clinical trials that are studying enema and capsule formulations for FMT.

Expertise and rankings

Mayo Clinic has 140 digestive disease specialists (gastroenterologists) on staff, one of the largest such groups in the world. Because of the complexity of digestive diseases, the specialty is divided into nine specialty groups.

Mayo Clinic resources include the latest in endoscopic equipment and techniques. Using these minimally invasive procedures, doctors insert tubes through the mouth, nose or rectum to examine and treat problems of the digestive tract.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

June 18, 2016
References
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  2. Longo DL, et al., eds. Clostridium difficile infection, including pseudomembranous colitis. In: Harrison's Principles of Internal Medicine. 19th ed. New York, N.Y.: McGraw-Hill Education; 2015. http://accessmedicine.com. Accessed Feb. 5, 2016.
  3. Cammarota G, et al. Fecal microbiota transplantation for the treatment of Clostridium difficile infection: A systematic review. Journal of Clinical Gastroenterology. 2014;48:693.
  4. Waltz P, et al. Novel therapies for severe Clostridium difficile colitis. Current Opinion in Critical Care. In press. Accessed Feb. 8, 2016.
  5. Malani PN, et al. Expanded evidence for frozen fecal microbiota transplantation for Clostridium difficile infection: A fresh take. JAMA. 2016;315:137.
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  8. Frequently asked questions about Clostridium difficile for healthcare providers. Centers for Disease Control and Prevention. http://www.cdc.gov/HAI/organisms/cdiff/Cdiff_faqs_HCP.html. Accessed Feb. 8, 2016.
  9. LaMont JT. Clostridium difficile in adults: Clinical manifestations and diagnosis. http://www.uptodate.com/home. Accessed Feb. 8, 2016.
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