Overview

Bullous pemphigoid (BUL-us PEM-fih-goid) is a rare skin condition that causes large, fluid-filled blisters. The blisters develop on areas of skin that often flex — such as the lower abdomen, upper thighs or armpits. Bullous pemphigoid is most common in people older than age 60.

Bullous pemphigoid occurs when your immune system attacks a thin layer of tissue below your outer layer of skin. The reason for this abnormal immune response is unknown, although it sometimes can be triggered by taking certain medications.

Treatment usually includes medications, such as prednisone, and other drugs that suppress the immune system. Bullous pemphigoid can be life-threatening, especially for older people who are already in poor health.

Nov. 14, 2015
References
  1. Murrell DF, et al. Management and prognosis of bullous pemphigoid. http://www.uptodate.com/home. Accessed Oct. 6, 2015.
  2. Bullous pemphigoid. Merck Manual Professional Version. http://www.merckmanuals.com/professional/dermatologic_disorders/bullous_diseases/bullous_pemphigoid.html?qt=pemphigoid&alt=sh. Accessed Oct. 6, 2015.
  3. Leiferman KM. Epidemiology and pathogenesis of bullous pemphigoid and mucous membrane pemphigoid. http://www.uptodate.com/home. Accessed Oct. 6, 2015.
  4. Leiferman KM. Clinical features and diagnosis of bullous pemphigoid and mucous membrane pemphigoid. http://www.uptodate.com/home. Accessed Oct. 6, 2015.
  5. Mustafa MB, et al. Oral mucosal manifestations of autoimmune skin diseases. Autoimmunity Reviews. 2015;14:930.