It's not clear what causes bone cancer, but doctors have found certain factors are associated with an increased risk, including:

  • Inherited genetic syndromes. Certain rare genetic syndromes passed through families increase the risk of bone cancer, including Li-Fraumeni syndrome and hereditary retinoblastoma.
  • Paget's disease of bone. This precancerous condition that affects older adults increases the risk of bone cancer.
  • Radiation therapy for cancer. Exposure to large doses of radiation, such as those given during radiation therapy for cancer, increases the risk of bone cancer in the future.
Sep. 12, 2013