Mayo Clinic conducts clinical trials to improve the diagnosis and treatment of bipolar disorder. Mayo is a leader in pharmacogenomics research, the study of how genetic factors can predict a person's response to a medication. One focus of Mayo Clinic research is connecting specific genetic profiles with responses to specific antidepressant drugs used to treat bipolar disorder.
Mayo Clinic psychiatrists are working with other specialists to determine the biological basis of bipolar disorder in children and to identify better, safer and more-effective treatments for children and teens.
Mayo Clinic is serving as the primary project site for establishing the Individualized Medicine Biobank for Bipolar Disorder. This large-scale biobank of bipolar type I and II disorders is intended to serve as a resource for the bipolar research community.
See a list of publications by Mayo Clinic doctors and researchers on bipolar disorder on PubMed, a service of the National Library of Medicine.
Feb. 10, 2015
- Bipolar and related disorders. In: Diagnostic and Statistical Manual of Mental Disorders DSM-5. 5th ed. Arlington, Va.: American Psychiatric Association; 2013. http://www.psychiatryonline.org. Accessed Dec. 10, 2014.
- Highlights of changes from DSM-IV-TR to DSM-5. American Psychiatric Publishing. http://www.dsm5.org/Pages/Default.aspx. Accessed Dec. 10, 2014.
- Depression. National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/depression/index.shtml. Accessed Dec. 10, 2014.
- Culpepper L. The diagnosis and treatment of bipolar disorder: Decision-making in primary care. The Primary Care Companion for CNS Disorders. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195640/. Accessed Dec. 10, 2014.
- Bipolar disorder in children and adolescents. National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/bipolar-disorder-in-children-and-adolescents/index.shtml. Accessed Dec. 11, 2014.
- Symbyax (prescribing information). Indianapolis, Ind.: Eli Lilly and Company; 2009. http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021520s041lbl.pdf. Accessed Dec. 11, 2014.
- Thronson LR, et al. Psychopharmacology. Medical Clinics of North America. 2014;98:927.
- Ravindran AV, et al. Complementary and alternative therapies as add-ons to pharmacotherapy for mood and anxiety disorders: A systematic review. Journal of Affective Disorders. 2013;150:707.
- Sarris J, et al. Bipolar disorder and complementary medicine: Current evidence, safety issues, and clinical considerations. Journal of Alternative and Complementary Medicine. 2011;17:881.
- Bipolar disorder in adults. National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/bipolar-disorder/complete-index.shtml. Accessed Dec. 10, 2014.
- Bipolar disorder in children and teens. National Alliance on Mental Illness. http://www.nami.org/Template.cfm?Section=By_Illness&template=/ContentManagement/ContentDisplay.cfm&ContentID=13107. Access Dec. 11, 2014.
- Bipolar disorder. National Alliance on Mental Illness. http://www.nami.org/Content/NavigationMenu/Mental_Illnesses/Bipolar1/Home_-_What_is_Bipolar_Disorder_.htm. Accessed Dec. 10, 2014.
- Cook, AJ. Decision Support System. Mayo Clinic, Rochester, Minn. Oct. 24, 2014.
- Birmaher B. Bipolar disorder in children and adolescents: Epidemiology, pathogenesis, clinical manifestations, and course. http://www.uptodate.com/home. Accessed Dec. 11, 2014.
- Veldic M (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 21, 2014.
- Picardi A, et al. Psychotherapy of mood disorders. Clinical Practice and Epidemiology in Mental Health. 2014;10:140.
- Frye MA, et al. Current landscape, unmet needs and future directions for treatment of bipolar depression. Journal of Affective Disorders. 2014;169S1:S17.
- Frye MA. Clinical practice. Bipolar disorder — A focus on depression. New England Journal of Medicine. 2011;364:51.