Can huperzine A prevent memory loss and improve cognitive function in people with Alzheimer's disease?
Answers from Brent A. Bauer, M.D.
Huperzine (HOOP-ur-zeen) A, a dietary supplement derived from the Chinese club moss Huperzia serrata, has received some interest as a potential treatment for Alzheimer's disease.
Huperzine A acts as a cholinesterase inhibitor — a type of medication that works by improving the levels of neurotransmitters in the brain. Small early studies suggest that huperzine A may improve memory and protect nerve cells, which could slow the cognitive decline associated with Alzheimer's.
A recent meta-analysis found evidence that huperzine A may significantly improve cognitive performance in patients with Alzheimer's disease. Another study suggests that huperzine A appears to have many protective effects on the brain in addition to its role as a cholinesterase inhibitor.
However, there is a lack of long-term safety data — most studies have lasted three months or less — and many participants in the trials experienced side effects, including nausea and vomiting. More studies are needed to determine possible benefits and long-term risks of huperzine A.
For now, most doctors don't recommend taking huperzine A because Food and Drug Administration-approved cholinesterase inhibitor medications are available that have been tested for safety and effectiveness.
The Alzheimer's Association recommends that you not take huperzine A if you're already taking a prescribed cholinesterase inhibitor, such as donepezil (Aricept), rivastigmine (Exelon) or galantamine (Razadyne). Taking both could increase your risk of serious side effects.
Consult with your doctor before starting any dietary supplement, including huperzine A.
Nov. 25, 2014
- Yang G, et al. Huperzine A for Alzheimer's disease: A systematic review and meta-analysis of randomized clinical trials. PLOS One. 2013;8:e74916.
- Alternative treatments. Alzheimer's Association. http://www.alz.org/alzheimers_disease_alternative_treatments.asp. Accessed Sept. 26, 2014.
- Xing S, et al. Huperzine A in the treatment of Alzheimer's disease and vascular dementia: A meta-analysis. Evidence-based Complementary and Alternative Medicine. 2014;2014:363985. In press. Accessed Sept. 26, 2014.
- Li J, et al. Huperzine A for Alzheimer's disease. Cochrane Database of Systematic Reviews. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005592.pub2/abstract. Accessed Sept. 26, 2014.
- Qian ZL, et al. Huperzine A: Is it an effective disease-modifying drug for Alzheimer's disease? Frontiers in Aging Neuroscience. 2014;6:1.