Can Ginkgo biloba prevent memory loss and improve cognitive function?
Answers from Brent A. Bauer, M.D.
Ginkgo biloba, derived from the leaves of the Ginkgo biloba tree, is often touted as a memory aid. But it appears unlikely that Ginkgo biloba can prevent age-related memory problems or memory loss associated with mild cognitive impairment or Alzheimer's disease.
A number of small, early studies showed modest improvements in cognitive function for older adults with dementia. However, a number of larger studies haven't been able to confirm that Ginkgo biloba prevents memory loss or slows the progression of cognitive decline or Alzheimer's disease in older adults.
Although several more-recent studies have found slight improvements in cognitive function for people taking Ginkgo biloba, most experts feel that Ginkgo biloba hasn't lived up to its early promise and don't recommend its use as a memory aid.
June 06, 2014
- Saper R. Clinical use of ginkgo biloba. http://www.uptodate.com/home. Accessed Feb. 13, 2014.
- Diamond BJ, et al. Ginkgo biloba. Psychiatric Clinics of North America, 2013;36:73.
- Laws KR, et al. Is Ginkgo biloba a cognitive enhancer in healthy individuals? A meta-analysis. Human Psychopharmacology Clinical and Experimental. 2012;27:527.
- Vella B, et al. Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer’s disease (GuidAge): A randomized placebo-controlled trial. Lancet Neurology. 2012;11:851.
- Amieva H, et al. Ginkgo biloba extract and long-term cognitive decline: A 20-year follow-up population-based study. PLOS One. 2013;8:e52755.
- Lewis JE, et al. A double-blind, randomized clinical trial of dietary supplementation on cognitive and immune functioning in healthy older adults. BMC Complementary and Alternative and Medicine. 2014;14:43.
- Kaschel R. Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers. Phytomedicine. 2011;18:1202.
- Yakoot M, et al. Effect of Memo, a natural formula combination, on mini-mental state examination scores in patients with mild cognitive impairment. Clinical Interventions in Aging. 2013;8:975.