DefinitionBy Mayo Clinic Staff
Adrenoleukodystrophy (uh-dree-noh-loo-koh-DIS-truh-fee) is a type of hereditary (genetic) condition that damages the membrane that insulates nerve cells in your brain (myelin sheath).
In adrenoleukodystrophy (ALD), your body can't break down very long-chain fatty acids (VLCFA), causing saturated VLCFAs to build up in your brain, nervous system and adrenal gland.
Dec. 12, 2014
- NINDS Adrenoleukodystrophy information page. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/adrenoleukodystrophy/adrenoleukodystrophy.htm. Accessed Oct. 11, 2014.
- X-linked adrenoleukodystrophy. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/x-linked-adrenoleukodystrophy. Accessed Oct. 11, 2014.
- Percy AK, et al. Adrenoleukodystrophy. http://www.uptodate.com/home. Accessed Oct. 11, 2014.
- Pagon RA, et al. GeneReviews. Seattle, Wash.: University of Washington, Seattle; 2012. http://www.ncbi.nlm.nih.gov/books/NBK1315/. Accessed Oct. 11, 2014.