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Thomas G. Brott, M.D.

  1. Neurologist

Departments

Location

  1. Jacksonville, Florida

Languages

English

Appointments

Thomas G. Brott, M.D., is a neurologist at Mayo Clinic hospital in Jacksonville, Florida who treats conditions that include: atrial fibrillation, cerebrovascular disease, intracranial hemorrhage, ischemic stroke, stroke and subarachnoid hemorrhage. He performs procedures that entail left atrial appendage closure, transplants, and therapeutic hypothermia. Dr. Brott is passionate about acute stroke therapy, hemostatic markers in acute ischemic stroke, aneurysmal subarachnoid hemorrhage, intracranial hemorrhage, and hypothermia for ischemic brain injury.

Dr. Brott received his medical degree from the University of Chicago, followed by his medical internship at Beth Israel Deaconess Medical Center in Boston, Massachusetts (formerly Beth Israel Hospital). He then completed his neurology residency at the Harvard Longwood Neurology Program in Boston. He has served as chair of the Stroke Council of the American Heart Association, vice-chair of the National Stroke Association and chair of the Advisory Committee to the Neurological Devices Panel of the FDA. He received the 2013 Clinical Research Prize and the 2017 Research Achievement Award conferred by the American Heart Association. Mayo Clinic honored him with the Distinguished Investigator award in 2014.

Dr. Brott has been the principal designer of the National Institutes of Health Stroke Scale, which is used worldwide as the examination tool for patients with stroke. He and his stroke team performed one of the first studies that identified the potential of tissue plasminogen activator (tPA) as an acute treatment for ischemic stroke. Subsequent studies by Dr. Brott and others led to approval of tPA as a safe and effective acute treatment for stroke by the Food and Drug Administration (FDA). Dr. Brott's team was the first to characterize the first minutes following onset of spontaneous intracerebral hemorrhage. He has served as principal investigator of multiple NIH-funded CREST trials with medical centers across the U.S. and Canada. Currently, Dr. Brott is the Director and national principal investigator for an international randomized trial called CREST-2 at 143 medical centers in the U.S., Canada, Spain, Israel, and Australia. The trial is funded by the National Institutes of Health (NIH) and compares treatments for severe narrowing of the carotid artery in patients who have not had a stroke or warning signs of stroke due to the narrowing.

  1. Cerebrovascular disease
  2. Intracranial hemorrhage
  3. Ischemic stroke
  4. Stroke
  5. Subarachnoid hemorrhage
  1. Therapeutic hypothermia
  • Acute stroke therapy
  • Hemostatic markers in acute ischemic stroke
  • Aneurysmal subarachnoid hemorrhage
  • Intracranial hemorrhage
  • Hypothermia for ischemic brain injury
  • Cerebrovascular disorders
  • Clinical outcomes after stroke and cardiac arrest
  • Atrial appendage obliteration in atrial fibrillation
  • Neurology of solid organ transplantation
  • Critical care
  • Hospital neurology
  1. 1978
    Fellow - Clinical Fellow in NeurologyHarvard Medical School
  2. 1978
    Resident - NeurologyHarvard Longwood Neurology Program, Beth Israel Hospital/Children's Hospital/Brigham and Women's Hospital
  3. 1975
    Internship - MedicineBeth Israel Hospital, Harvard Medical School
  4. 1974
    MDUniversity of Chicago
  5. 1972
    MD - Urban Studies FellowshipUniversity Of Chicago Pritzker School Of Medicine
  6. 1970
    MD - Special StudentGraduate School of Arts and Sciences, Harvard University
  7. 1969
    ABHarvard College

Certifications

  1. 1979
    NeurologyAmerican Board of Psychiatry and Neurology

Awards and honors

  1. 2023
    2023 Innovation Award winner for the Society of Vascular and Interventional NeurologySociety of Vascular and Interventional Neurology
  2. 2017
    2017 Research Achievement AwardAmerican Heart Association
  3. 2014
    Distinguished Mayo InvestigatorMayo Clinic in Florida
  4. 2013
    2013 Clinical Research PrizeAmerican Heart Association
  5. 2013
    2013 Mayo Clinic- Karolinska Institute Collaborative Travel AwardKarolinska Institute
  6. 2010
    Researcher of the YearDepartment of Neurology
  7. 2008
    Researcher of the YearDepartment of Neurology
  8. 1999
    Robert E. and Clarice Smith FellowshipAwarding Organization
  9. 1998
    Samuel Kaplan, M.D. Visionary Award for Excellence in ResearchCincinnati Division, American Heart Association
  10. 1997
    Research Merit AwardOhio Affiliate, American Heart Association
  11. 1997
    Stroke Council William Feinberg Award for Excellence in Clinical StrokeAmerican Heart Association
  12. 1992
    Best DoctorsBest Doctors, Inc.
  13. 1974
    Alpha Omega AlphaAlpha Omega Alpha Honor Medical Society
  14. 1974
    Upjohn Achievement Award in MedicineUniversity of Chicago
  15. 1973
    Representative for Division of Biological Sciences to the President's Seminar (One representative per Division)University of Chicago
  16. 1971
    Urban Studies FellowshipUniversity Of Chicago Pritzker School Of Medicine
  17. 1969
    cum laude in general studiesHarvard College

Professional memberships

  1. 2013
    MemberAdvisory Council to the Executive Dean for Research, Mayo Clinic Committees
  2. 2013
    MemberPI Search Committee, Mayo Clinic Center for Translational Science Activities
  3. 2010
    ChairInternal Medicine Search Committee
  4. 2010
    MemberHematology/Oncology Search Committee, Mayo Clinic Florida Committees
  5. 2009 - 2016
    ConsultantNeurological Devices Panel, Food and Drug Administration
  6. 2008 - present
    MemberHuman Embyronic Stem Cell Research Oversight Subcommittee, Mayo Clinic Research Committee, Mayo Clinic Rochester Committees
  7. 2008 - 2013
    Advisory Council MemberNational Institute of Neurological Disorders and Stroke, National Institutes of Health
  8. 2008 - present
    Board MemberBrooks Health System
  9. 2005
    MemberSpecial Emphasis Panel, National Heart, Lung, and Blood Institute, National Institutes of Health
  10. 2005 - 2008
    ChairNeurological Devices Panel, Food and Drug Administration
  11. 2005 - 2006
    MemberAdministrative Committee of the Board, Mayo Clinic Florida Committees
  12. 2005 - 2006
    MemberDevelopment Committee, Mayo Clinic Florida Committees
  13. 2005
    ConsultantCirculatory System Devices Panel, Food and Drug Administration
  14. 2005 - present
    MemberPersonnel Committee, Mayo Clinic Florida Committees
  15. 2004 - 2008
    MemberNeurological Devices Panel, Food and Drug Administration
  16. 2001 - present
    FellowAmerican Heart Association
  17. 2000 - 2004
    Vice ChairNational Stroke Association
  18. 2000 - 2001
    ChairAwards Committee, American Stroke Association
  19. 1999 - 2001
    MemberBoard of Directors, Florida First Coast Division, American Heart Association
  20. 1999 - present
    MemberResearch Committee, Mayo Clinic Florida Committees
  21. 1998 - 1999
    MemberNSA Negotiation Task Force, American Heart Association
  22. 1998 - present
    FellowAmerican Academy of Neurology
  23. 1997 - 1999
    ChairStroke Council, American Heart Association
  24. 1997 - 1999
    MemberAwards and International Affairs Committee, American Heart Association
  25. 1995
    Oral ExaminerPart II Oral Examinations, American Board of Psychiatry and Neurology
  26. 1995 - 1998
    MemberExecutive Council, Joint Section on Cerebrovascular Surgery, American Association of Neurological Surgeons/Congress of Neurological Surgeons
  27. 1995 - 1998
    MemberNational Study Committee (Brain), American Heart Association
  28. 1995 - present
    MemberAmerican Neurological Association
  29. 1994 - 1998
    MemberLong Range Planning/Nominating Committee, Stroke Council, American Heart Association
  30. 1994 - 1997
    Vice ChairExecutive Committee, Stroke Council, American Heart Association
  31. 1993 - 2004
    MemberBoard of Directors, National Stroke Association
  32. 1993 - 1996
    Member19th International Joint Conference on Stroke and Cerebral Circulation Program Committee, Stroke Council, American Heart Association
  33. 1993 - 1995
    ChairMembership and Credentials Committee, Stroke Council, American Heart Association
  34. 1993 - 1994
    MemberPublic Affairs Committee, Stroke Council, American Heart Association
  35. 1993 - present
    MemberExecutive Committee, Stroke Council, American Heart Association
  36. 1992 - 1998
    ParticipantNeuroscience Program, University of Cincinnati
  37. 1992 - 1998
    MemberAmerican Society of Neuroimaging
  38. 1992 - 1993
    Nominations ChairCincinnati Division, Executive Committee, American Heart Association
  39. 1991
    Oral ExaminerPart II Oral Examinations, American Board of Psychiatry and Neurology
  40. 1991 - 1994
    Member-at-LargeExecutive Committee, Stroke Council, American Heart Association
  41. 1991 - 1994
    MemberMembership and Credentials Committee, Stroke Council, American Heart Association
  42. 1990 - 1992
    PresidentSouthwest Ohio Chapter, American Heart Association
  43. 1990 - 1991
    MemberExecutive Committee, Ohio Affiliate, American Heart Association
  44. 1990
    ChairCommittee for Review of the Director, Department of Surgery, College of Medicine
  45. 1990 - present
    MemberSection of Critical Care and Emergency Neurology, American Academy of Neurology
  46. 1989
    Oral ExaminerPart II Oral Examinations, American Board of Psychiatry and Neurology
  47. 1989 - 1990
    Vice PresidentSouthwest Ohio Chapter, American Heart Association
  48. 1988
    Oral ExaminerPart II Oral Examinations, American Board of Psychiatry and Neurology
  49. 1988 - 1992
    Board MemberOhio Affiliate, American Heart Association
  50. 1988 - 1990
    MemberSpecial Care Unit Committee, University of Cincinnati Medical Center
  51. 1987 - 1998
    ChairResearch and Development Committee, Department of Neurology, University of Cincinnati
  52. 1987 - 1990
    Medical DirectorNeuroscience Intensive Care Unit, University of Cincinnati
  53. 1986 - 1991
    MemberEducation Committee, Department of Neurology, University of Cincinnati
  54. 1986 - 1989
    Member-at-LargeExecutive Committee, University of Cincinnati Medical Center
  55. 1986 - 1987
    MemberDepartmental Review Committee, University of Cincinnati
  56. 1985 - 1998
    Board MemberSouthwest Ohio Chapter, American Heart Association
  57. 1985 - 1987
    Liaison to Medical LibraryDepartment of Neurology, University of Cincinnati
  58. 1985 - 1987
    MemberAir Care Committee, University of Cincinnati
  59. 1985 - 1987
    MemberNeurology/Neurosurgery Special Care Unit Planning Committee, University of Cincinnati
  60. 1983 - 1985
    MemberFaculty Practice Committee, Department of Neurology, University of Cincinnati
  61. 1983 - present
    MemberStroke Council, American Heart Association
  62. 1976 - present
    MemberAmerican Academy of Neurology
  63.  
    MemberExternal Advisory Committee, Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) Grant, University of Cincinnati
  64.  
    MemberSection on Neurological Epidemiology, American Academy of Neurology
  65.  
    MemberSection on Neuroimaging, American Academy of Neurology
  66.  
    MemberSection on Stroke, American Academy of Neurology

Publications

Research activities

See a description of research activities.