الأدوية والمكملات الغذائية

Proper Use

Drug information provided by: Merative, Micromedex®

This medicine is given as a shot under your skin, usually in the stomach, thighs, or upper arms.

Alirocumab may sometimes be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, your doctor will teach you how to prepare and inject the medicine. Be sure that you understand exactly how the medicine is prepared and injected.

This medicine should come with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

This medicine comes in 2 forms: single-dose prefilled pen (autoinjector) and single-dose prefilled syringe. Your doctor will prescribe the type and dose that is right for you.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections.

Do not inject other medicines together with alirocumab injection at the same injection site.

Do not inject on skin areas that are bruised, red, hard, or tender.

Allow the medicine to warm to room temperature for at least 30 to 40 minutes before using it. Do not warm it in any other way. Do not shake the medicine.

Use each autoinjector pen or syringe only one time. Do not save an open pen or syringe. If the medicine in the pen or syringe has changed color, or if you see particles in it, do not use it.

In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Carefully follow your doctor's order about any special diet.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  • For primary hyperlipidemia and lowering the risk of heart attack, stroke, and chest pain:
    • Adults—
      • Every 2-week dose: 75 milligrams (mg) injected under your skin once every 2 weeks. Your doctor may increase your dose as needed. However, the dose is usually not more than 150 mg injected under your skin once every 2 weeks.
      • Every 4-week dose: 300 mg injected under your skin once every 4 weeks, given as two 150 mg injections at two different sites. Your doctor may adjust your dose as needed. However, the dose is usually not more than 150 mg injected under your skin once every 2 weeks.
    • Children—Use and dose must be determined by your doctor.
  • For homozygous familial hypercholesterolemia:
    • Adults—150 milligrams (mg) injected under your skin once every 2 weeks.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

Every 2-week dose: If you missed a dose, use this medicine within 7 days from the missed dose. Then, go back to your original schedule. If the missed dose is not given within 7 days, wait until your next scheduled dose to re-start alirocumab. If you are not sure when to re-start alirocumab, ask your doctor or pharmacist.

Every 4-week dose: If you missed a dose, use this medicine within 7 days from the missed dose. Then, go back to your original schedule. If the missed dose is not given within 7 days, use this medicine right away and re-start alirocumab based on this date. If you are not sure when to re-start alirocumab, ask your doctor or pharmacist.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may also store this medicine in its original carton at room temperature for up to 30 days. Do not expose to extreme heat. After removing this medicine from the refrigerator, use it within 30 days. Throw away any unused medicine after 30 days.

Throw away used needles in a hard, closed container where the needles cannot poke through. Keep this container away from children and pets.