Description and Brand Names

药物信息提供方:IBM Micromedex

US Brand Name

  1. Zaltrap


Ziv-aflibercept injection is given together with other medicines (eg, fluorouracil, irinotecan, leucovorin) to treat advanced cancer of the colon or rectum. It is used in patients who have already been treated with other cancer medicines that did not work well. Ziv-aflibercept works by changing the amount of blood that gets to the tumor.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of ziv-aflibercept injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ziv-aflibercept injection in the elderly. However, elderly patients are more likely to have unwanted effects (eg, diarrhea, dehydration), which may require caution in patients receiving ziv-aflibercept injection.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (severe chest pain) or
  • Bleeding problems or
  • Blood clotting problems or
  • Heart attack, history of or
  • Hypertension (high blood pressure) or
  • Kidney disease or
  • Neutropenia (low white blood cells) or
  • Proteinuria (protein in the urine), history of or
  • Stomach or intestinal problems (eg, diarrhea, bleeding, fistula, perforation), history of or
  • Transient ischemic attacks (TIA or small strokes), history of or
  • Wound healing problems—Use with caution. May make these conditions worse.

Proper Use

A nurse or other trained health professional will give you this medicine in a hospital or cancer treatment center. This medicine is given through a needle placed in a vein for at least 1 hour and is given together with other cancer medicines every 2 weeks.


Your doctor will want to check your progress at regular visits to see if the medicine is working properly and to decide if you should continue to receive it.

Your doctor will check your blood, urine, and blood pressure on a regular basis while you are receiving this medicine. You may also need to monitor your blood pressure at home. If you notice any changes to your normal blood pressure, call your doctor right away.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 1 month after the last dose. If you think you have become pregnant, tell your doctor right away.

This medicine may increase your chance of having bleeding problems. Call your doctor right away if you notice any signs of bleeding, such as bloody or black, tarry stools, blood in the urine, lightheadedness, shortness of breath, or vomiting of blood that looks like coffee grounds.

Call your doctor right away if you have severe diarrhea, nausea, vomiting, or stomach pain. These may be symptoms of a serious stomach problem.

This medicine may affect the way your body heals from cuts and wounds. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several weeks before having surgery.

This medicine may increase your risk of having blood clots. Check with your doctor right away if you have severe headaches of sudden onset, sudden loss of coordination, pains in the chest, groin, or legs, especially calves of legs, sudden onset of shortness of breath for no apparent reason, sudden onset of slurred speech, or sudden vision changes.

Check with your doctor right away if you have a headache, seizures, confusion, blurred vision or other visual problems. These may be symptoms of a rare and serious brain condition called reversible posterior leukoencephalopathy syndrome (RPLS).

Ziv-aflibercept can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
  • Check with your doctor immediately if you start to cough up blood or if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
  • Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
  • Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
  • Avoid contact sports or other situations where bruising or injury could occur.

If you plan to have children, talk with your doctor before using this medicine. Some men and women using this medicine have become infertile (unable to have children).

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Anxiety
  2. black, tarry stools
  3. bladder pain
  4. bleeding gums
  5. blood in the urine or stools
  6. bloody nose
  7. blurred vision
  8. chest pain
  9. confusion
  10. cough or hoarseness
  11. decreased urination
  12. difficult, burning, or painful urination
  13. dizziness or lightheadedness
  14. dry mouth
  15. excessive thirst
  16. fainting
  17. fever or chills
  18. frequent urge to urinate
  19. headache
  20. hoarseness
  21. lower back or side pain
  22. nervousness
  23. pain or swelling around the rectum
  24. pale skin
  25. pinpoint red spots on the skin
  26. pounding in the ears
  27. slow or fast heartbeat
  28. sore throat
  29. sores, ulcers, or white spots on the lips or in the mouth
  30. sudden shortness of breath or troubled breathing
  31. sunken eyes
  32. swollen glands
  33. unusual bleeding or bruising
  34. unusual tiredness or weakness
  35. voice changes
  36. wrinkled skin

Less common

  1. Pains in the chest, groin, or legs, especially calves of the legs
  2. severe headaches of sudden onset
  3. sudden loss of coordination
  4. sudden onset of shortness of breath for no apparent reason
  5. sudden onset of slurred speech
  6. sudden vision changes
  7. troubled breathing


  1. Heartburn
  2. indigestion
  3. nausea
  4. severe abdominal or stomach pain, cramping, or burning
  5. vomiting of material that looks like coffee grounds, severe and continuing

Incidence not known

  1. Dilated neck veins
  2. extreme fatigue
  3. irregular breathing
  4. irregular heartbeat
  5. swelling of the face, fingers, feet, or lower legs
  6. tightness in the chest
  7. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Abdominal or stomach pain
  2. decreased appetite
  3. diarrhea
  4. lack or loss of strength
  5. redness, swelling, or pain of the skin
  6. runny nose
  7. scaling of the skin on the hands and feet
  8. swelling or inflammation of the mouth
  9. tingling of the hands and feet
  10. ulceration of the skin

Incidence not known

  1. Heavy jaw feeling
  2. loosening of a tooth
  3. pain, swelling, or numbness in the mouth or jaw

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.