Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Do not give a medicine containing aspirin to a child or teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing this with your child's doctor. This is very important because aspirin may cause a serious illness called Reye's syndrome in children or teenagers with fever caused by a virus infection, especially flu or chickenpox. Children who do not have a virus infection may also be more sensitive to the effects of aspirin (contained in this combination medicine), especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. This may increase the chance of side effects during treatment.

Geriatric

Elderly people may be especially sensitive to the effects of meprobamate and aspirin. This may increase the chance of side effects during treatment.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Abrocitinib
  • Defibrotide
  • Dichlorphenamide
  • Influenza Virus Vaccine, Live
  • Ketorolac

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Acetazolamide
  • Alclometasone
  • Aldosterone
  • Alfentanil
  • Alipogene Tiparvovec
  • Alprazolam
  • Alteplase, Recombinant
  • Amcinonide
  • Amikacin
  • Amiloride
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amobarbital
  • Amoxapine
  • Amphotericin B
  • Amtolmetin Guacil
  • Anagrelide
  • Anisindione
  • Apixaban
  • Aprobarbital
  • Ardeparin
  • Argatroban
  • Bacitracin
  • Beclomethasone
  • Bemetizide
  • Bemiparin
  • Benazepril
  • Bendroflumethiazide
  • Benzhydrocodone
  • Benzthiazide
  • Betamethasone
  • Betrixaban
  • Bivalirudin
  • Brinzolamide
  • Bromazepam
  • Bromfenac
  • Bromopride
  • Budesonide
  • Bufexamac
  • Bumetanide
  • Buprenorphine
  • Butabarbital
  • Butalbital
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cannabis
  • Caplacizumab-yhdp
  • Capreomycin
  • Captopril
  • Carbinoxamine
  • Carisoprodol
  • Celecoxib
  • Certoparin
  • Cetirizine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Chlorzoxazone
  • Choline Salicylate
  • Ciclesonide
  • Cilostazol
  • Cisplatin
  • Citalopram
  • Clobazam
  • Clobetasol
  • Clobetasone
  • Clocortolone
  • Clomipramine
  • Clonazepam
  • Clonixin
  • Clopamide
  • Clopidogrel
  • Clorazepate
  • Codeine
  • Cortisone
  • Curcumin
  • Cyclopenthiazide
  • Cyclosporine
  • Cyclothiazide
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Dantrolene
  • Daridorexant
  • Deflazacort
  • Desipramine
  • Desirudin
  • Desmopressin
  • Desonide
  • Desoximetasone
  • Desvenlafaxine
  • Dexamethasone
  • Dexibuprofen
  • Dexketoprofen
  • Dexmedetomidine
  • Diazepam
  • Diazoxide
  • Dibenzepin
  • Diclofenac
  • Dicumarol
  • Diflorasone
  • Diflucortolone
  • Diflunisal
  • Difluprednate
  • Digoxin
  • Dihydrocodeine
  • Dipyrone
  • Dorzolamide
  • Dothiepin
  • Doxepin
  • Doxylamine
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Emtricitabine
  • Enalapril
  • Enalaprilat
  • Enoxaparin
  • Eplerenone
  • Eptifibatide
  • Escitalopram
  • Esketamine
  • Eslicarbazepine Acetate
  • Estazolam
  • Ethacrynic Acid
  • Ethchlorvynol
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Etozolin
  • Felbinac
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Feverfew
  • Flibanserin
  • Floctafenine
  • Flucloronide
  • Fluconazole
  • Fludrocortisone
  • Flufenamic Acid
  • Flumethasone
  • Flunisolide
  • Flunitrazepam
  • Fluocinolone
  • Fluocinonide
  • Fluocortin
  • Fluocortolone
  • Fluorometholone
  • Fluoxetine
  • Flurandrenolide
  • Flurazepam
  • Flurbiprofen
  • Fluticasone
  • Fluvoxamine
  • Fondaparinux
  • Foscarnet
  • Fosinopril
  • Fosphenytoin
  • Fospropofol
  • Furosemide
  • Gabapentin
  • Gabapentin Enacarbil
  • Gentamicin
  • Ginkgo
  • Glimepiride
  • Glipizide
  • Glyburide
  • Gossypol
  • Halazepam
  • Halcinonide
  • Halobetasol
  • Heparin
  • Hydrochlorothiazide
  • Hydrocodone
  • Hydrocortisone
  • Hydroflumethiazide
  • Hydromorphone
  • Ibrutinib
  • Ibuprofen
  • Imipramine
  • Indapamide
  • Indomethacin
  • Inotersen
  • Kanamycin
  • Ketamine
  • Ketazolam
  • Ketoprofen
  • Lacosamide
  • Lemborexant
  • Lepirudin
  • Levocetirizine
  • Levomilnacipran
  • Levorphanol
  • Lisinopril
  • Lithium
  • Lofepramine
  • Lofexidine
  • Lorazepam
  • Lormetazepam
  • Lornoxicam
  • Loteprednol
  • Loxapine
  • Loxoprofen
  • Lumiracoxib
  • Macimorelin
  • Magnesium Oxybate
  • Meclizine
  • Meclofenamate
  • Medazepam
  • Medrysone
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Melphalan
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Metaxalone
  • Metformin
  • Methadone
  • Methazolamide
  • Methocarbamol
  • Methohexital
  • Methotrexate
  • Methyclothiazide
  • Methylprednisolone
  • Metoclopramide
  • Metolazone
  • Midazolam
  • Milnacipran
  • Moexipril
  • Mometasone
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nabumetone
  • Nadroparin
  • Nalbuphine
  • Naproxen
  • Nateglinide
  • Nefazodone
  • Neomycin
  • Nepafenac
  • Netilmicin
  • Nicorandil
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nitrazepam
  • Nortriptyline
  • Olanzapine
  • Oliceridine
  • Opipramol
  • Oxaprozin
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Oxyphenbutazone
  • Paramethasone
  • Parecoxib
  • Parnaparin
  • Paromomycin
  • Paroxetine
  • Pemetrexed
  • Pentazocine
  • Pentobarbital
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Periciazine
  • Perindopril
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Phenylbutazone
  • Phenytoin
  • Piketoprofen
  • Piracetam
  • Piretanide
  • Piroxicam
  • Plazomicin
  • Polythiazide
  • Potassium Citrate
  • Potassium Oxybate
  • Pranoprofen
  • Prasugrel
  • Prazepam
  • Prednicarbate
  • Prednisolone
  • Prednisone
  • Pregabalin
  • Primidone
  • Proglumetacin
  • Propofol
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Quazepam
  • Quinapril
  • Quinethazone
  • Ramipril
  • Remifentanil
  • Remimazolam
  • Repaglinide
  • Reteplase, Recombinant
  • Reviparin
  • Rimexolone
  • Rivaroxaban
  • Rofecoxib
  • Ropeginterferon Alfa-2b-njft
  • Salicylic Acid
  • Salsalate
  • Scopolamine
  • Secobarbital
  • Selumetinib
  • Sertraline
  • Sodium Oxybate
  • Sodium Salicylate
  • Sparsentan
  • Spectinomycin
  • Spirapril
  • Spironolactone
  • Streptomycin
  • Sufentanil
  • Sulindac
  • Sulodexide
  • Tacrolimus
  • Tapentadol
  • Temazepam
  • Tenofovir Alafenamide
  • Tenofovir Disoproxil Fumarate
  • Tenoxicam
  • Thiopental
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tobramycin
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trazodone
  • Treprostinil
  • Triamcinolone
  • Triamterene
  • Triazolam
  • Trichlormethiazide
  • Trimipramine
  • Turmeric
  • Valdecoxib
  • Valproic Acid
  • Vancomycin
  • Varicella Virus Vaccine, Live
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin
  • Xipamide
  • Zolpidem
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Delapril
  • Esmolol
  • Imidapril
  • Labetalol
  • Levobunolol
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Nitroglycerin
  • Oxprenolol
  • Penbutolol
  • Pindolol
  • Probenecid
  • Propranolol
  • Sotalol
  • Streptokinase
  • Tamarind
  • Temocapril
  • Tenecteplase
  • Timolol

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of) or
  • Drug abuse or dependence (or history of)—Dependence on meprobamate may develop
  • Anemia or
  • Stomach ulcer or other stomach problems—Aspirin may make your condition worse
  • Asthma, allergies, and nasal polyps (history of) or
  • Kidney disease or
  • Liver disease—The chance of side effects may be increased.
  • Epilepsy—The risk of seizures may be increased
  • Gout—Aspirin may make this condition worse and may also lessen the effects of some medicines used to treat gout
  • Hemophilia or other bleeding problems—The chance of bleeding may be increased by aspirin
  • Porphyria—Meprobamate may make the condition worse

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.