Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

1. Zokinvy

Descriptions

Lonafarnib is used to help reduce the risk of death in patients with Hutchinson-Gilford Progeria Syndrome (HGPS). HGPS is a genetic condition in which patients have a noticeable, rapid appearance of aging beginning in childhood.

Lonafarnib is also used to treat rare genetic disorders called processing-deficient Progeroid Laminopathies in patients with either heterozygous LMNA mutation with progerin-like protein accumulation, or homozygous or compound heterozygous ZMPSTE24 mutations.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Capsule

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of lonafarnib in children younger than 12 months of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lonafarnib in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Apalutamide
• Atorvastatin
• Bepridil
• Boceprevir
• Bosentan
• Carbamazepine
• Cenobamate
• Ceritinib
• Cisapride
• Clarithromycin
• Cobicistat
• Colchicine
• Dabrafenib
• Dihydroergotamine
• Dipyrone
• Dronedarone
• Efavirenz
• Elagolix
• Enzalutamide
• Etravirine
• Fosphenytoin
• Gepirone
• Idelalisib
• Indinavir
• Isavuconazonium Sulfate
• Itraconazole
• Ivacaftor
• Ivosidenib
• Ketoconazole
• Lorlatinib
• Lovastatin
• Lumacaftor
• Mavacamten
• Mesoridazine
• Midazolam
• Mifepristone
• Mitotane
• Modafinil
• Nafcillin
• Nefazodone
• Nelfinavir
• Paritaprevir
• Phenobarbital
• Phenytoin
• Pimozide
• Piperaquine
• Posaconazole
• Primidone
• Repotrectinib
• Ribociclib
• Rifabutin
• Rifampin
• Rifapentine
• Ritonavir
• Saquinavir
• Simvastatin
• Sparfloxacin
• St John's Wort
• Telaprevir
• Telithromycin
• Telotristat Ethyl
• Terfenadine
• Thioridazine
• Troleandomycin
• Tucatinib
• Voriconazole
• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abemaciclib
• Acalabrutinib
• Adagrasib
• Alfentanil
• Alfuzosin
• Amiodarone
• Amisulpride
• Amitriptyline
• Amprenavir
• Anagrelide
• Apomorphine
• Aprepitant
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Asciminib
• Asenapine
• Astemizole
• Atazanavir
• Avanafil
• Avapritinib
• Axitinib
• Azithromycin
• Bedaquiline
• Berotralstat
• Bosutinib
• Brigatinib
• Budesonide
• Buprenorphine
• Buserelin
• Buspirone
• Capivasertib
• Carisoprodol
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Citalopram
• Clindamycin
• Clobazam
• Clofazimine
• Clomipramine
• Clopidogrel
• Clozapine
• Cobimetinib
• Conivaptan
• Crizotinib
• Cyclobenzaprine
• Cyclosporine
• Dabigatran Etexilate
• Daridorexant
• Darifenacin
• Darunavir
• Dasatinib
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dexlansoprazole
• Diazepam
• Digoxin
• Diltiazem
• Disopyramide
• Docetaxel
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Droperidol
• Duvelisib
• Ebastine
• Elacestrant
• Eletriptan
• Elexacaftor
• Elvitegravir
• Encorafenib
• Entrectinib
• Eplerenone
• Erdafitinib
• Ergotamine
• Eribulin
• Erythromycin
• Escitalopram
• Esomeprazole
• Etrasimod
• Everolimus
• Famotidine
• Fedratinib
• Felbamate
• Felodipine
• Fentanyl
• Fexinidazole
• Finerenone
• Fingolimod
• Flecainide
• Flibanserin
• Fluconazole
• Fluoxetine
• Fluticasone
• Formoterol
• Fosamprenavir
• Fosaprepitant
• Foscarnet
• Fosnetupitant
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Glasdegib
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibrexafungerp
• Ibrutinib
• Ibutilide
• Iloperidone
• Imatinib
• Imipramine
• Inotuzumab Ozogamicin
• Irinotecan
• Irinotecan Liposome
• Ivabradine
• Labetalol
• Lansoprazole
• Lapatinib
• Lefamulin
• Lenvatinib
• Letermovir
• Leuprolide
• Levofloxacin
• Levoketoconazole
• Levomethadyl
• Levomilnacipran
• Lofexidine
• Lomitapide
• Loperamide
• Lopinavir
• Lumefantrine
• Lurasidone
• Lurbinectedin
• Macimorelin
• Macitentan
• Maraviroc
• Mefloquine
• Methadone
• Methotrimeprazine
• Metronidazole
• Midostaurin
• Mizolastine
• Mobocertinib
• Moricizine
• Moxifloxacin
• Nafarelin
• Naloxegol
• Neratinib
• Netupitant
• Nifedipine
• Nilotinib
• Nirmatrelvir
• Nirogacestat
• Nisoldipine
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Olaparib
• Oliceridine
• Omeprazole
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxycodone
• Paclitaxel
• Paliperidone
• Palovarotene
• Panobinostat
• Pantoprazole
• Papaverine
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Perphenazine
• Pimavanserin
• Pipamperone
• Pitolisant
• Ponesimod
• Pralsetinib
• Probucol
• Procainamide
• Prochlorperazine
• Progesterone
• Proguanil
• Promethazine
• Propafenone
• Protriptyline
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Quizartinib
• Rabeprazole
• Ranolazine
• Risperidone
• Ritlecitinib
• Rivaroxaban
• Roflumilast
• Ruxolitinib
• Schisandra sphenanthera
• Selpercatinib
• Sertindole
• Sertraline
• Sevoflurane
• Sibutramine
• Sildenafil
• Siponimod
• Sirolimus
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sonidegib
• Sorafenib
• Sotalol
• Sufentanil
• Sulpiride
• Sultopride
• Sunitinib
• Tacrolimus
• Tadalafil
• Tamoxifen
• Telavancin
• Temsirolimus
• Tetrabenazine
• Tezacaftor
• Ticagrelor
• Tipranavir
• Tolterodine
• Tolvaptan
• Toremifene
• Tramadol
• Trazodone
• Triazolam
• Triclabendazole
• Trimipramine
• Triptorelin
• Ubrogepant
• Ulipristal
• Valbenazine
• Vamorolone
• Vandetanib
• Vardenafil
• Vemurafenib
• Venetoclax
• Venlafaxine
• Verapamil
• Vilanterol
• Vilazodone
• Vinflunine
• Voclosporin
• Vorinostat
• Voxelotor
• Zanubrutinib
• Zolpidem
• Zotepine
• Zuclopenthixol
• Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amlodipine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Bitter Orange
• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bradycardia (slow heartbeat) or
• Eye or vision problems or
• Heart rhythm problems, history of or
• Hypomagnesemia (low magnesium in the blood) or
• Hypokalemia (low potassium in the blood)—Use with caution. May make these conditions worse.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take it more often, and do not take it for a longer time than your doctor ordered. Do not stop taking this medicine without first checking with your doctor.

This medicine usually comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions.

Swallow the capsule whole with water. Do not chew it.

It is best to take this medicine with food.

If you cannot swallow the capsule whole, you may open it and mix the medicine with Ora Blend SF®, Ora-Plus®, orange juice, or applesauce. The mixture must be prepared fresh for each dose and taken within at least 10 minutes of mixing.

Do not eat grapefruit or Seville oranges while you are using this medicine. Do not mix this medicine with juice containing grapefruit or Seville oranges.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules):
  • For Hutchinson-Gilford Progeria Syndrome and processing-deficient Progeroid Laminopathies:
    • Adults and children 12 months of age and older with a body surface area (BSA) of 0.39 meter squared (m2)—At first, 115 milligrams per square meter (mg/m[2]), taken 2 times a day with the morning and evening meals. Your doctor may adjust your dose as needed and tolerated.
    • Children younger than 12 months of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose and it is 8 hours or more until your next scheduled dose, take it as soon as possible, and then go back to your regular schedule. If you miss a dose and it is less than 8 hours until your next scheduled dose, skip the missed dose and take your next dose at the regular time.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment. If you think you have become pregnant while using the medicine, tell your doctor right away.

Do not use this medicine together with atorvastatin, ketoconazole, lovastatin, rifampin, or simvastatin. Do not use this medicine for 10 to 14 days before and 2 days after using midazolam.

This medicine may cause heart rhythm problems (eg, QT prolongation). Check with your doctor right away if you have dizziness, lightheadedness, fainting, or fast or irregular heartbeat.

This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

This medicine may cause kidney problems. Check with your doctor right away if you or your child have agitation, blood in the urine, coma, confusion, decreased urine output, depression, dizziness, headache, irritability, lethargy, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

Check with your doctor right away if eye pain or a change in vision occurs during treatment. These could be a sign of a serious eye problem. Your doctor may want your eyes to be checked by an ophthalmologist (eye doctor).

This medicine may cause infertility (unable to have children) in some patients. Talk with your doctor before using this medicine if you plan to have children.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Agitation
2. black, tarry stools
3. blood in the urine or stools
4. burning, dry, or itching eyes
5. changes in the eye
6. coma
7. cough or hoarseness
8. confusion
9. dark urine
10. decreased appetite
11. decreased urine output
12. depression
13. diarrhea
14. discharge, excessive tearing
15. dizziness, lightheadedness, or fainting
16. fast or irregular heartbeat
17. fever
18. headache
19. irritability
20. lethargy
21. light-colored stools
22. lower back or side pain
23. muscle twitching
24. nausea
25. painful or difficult urination
26. pinpoint red spots on the skin
27. rapid weight gain
28. redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
29. seizures
30. sore throat
31. stomach pain or bloating
32. stupor
33. swelling of the face, ankles, or hands
34. unusual bleeding or bruising
35. unusual tiredness or weakness
36. vomiting
37. weight loss
38. yellow eyes or skin

Less common

1. Body aches or pain
2. chills
3. cough
4. difficulty in breathing
5. ear congestion
6. fever
7. headache
8. loss of voice
9. runny or stuffy nose
10. sneezing
11. sore throat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Bloated
2. bloody nose
3. constipation
4. excess air or gas in the stomach or bowels
5. full feeling
6. passing gas

Less common

1. Cracked lips
2. difficulty in swallowing
3. itching skin
4. sores, ulcers, or white spots in the lips, tongue, or inside the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: June 01, 2024

Original article: https://www.mayoclinic.org/zh-hans/drugs-supplements/lonafarnib-oral-route/description/drg-20506373