Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Black, tarry stools
  2. bleeding gums
  3. blood in the urine or stools
  4. cough or hoarseness
  5. coughing up blood
  6. difficulty with breathing or swallowing
  7. dizziness
  8. fever or chills
  9. headache
  10. increased menstrual flow or vaginal bleeding
  11. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  12. lower back or side pain
  13. noisy breathing
  14. nosebleeds
  15. painful or difficult urination
  16. pale skin
  17. paralysis
  18. pinpoint red spots on the skin
  19. prolonged bleeding from cuts
  20. red or dark brown urine
  21. red stools
  22. shortness of breath
  23. sore throat
  24. sores, ulcers, or white spots on the lips or in the mouth
  25. swollen glands
  26. tightness in the chest
  27. troubled breathing with exertion
  28. unusual bleeding or bruising
  29. unusual tiredness or weakness
  30. wheezing

Less common

  1. Bloody nose that does not stop after pinching the nose together and holding it for 5 to 10 minutes
  2. bluish lips or skin
  3. chest pain or discomfort
  4. confusion
  5. diarrhea
  6. fainting
  7. fast heartbeat
  8. hives
  9. itching
  10. lightheadedness
  11. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  12. rapid, shallow breathing
  13. skin rash
  14. small red or purple spots on the skin
  15. unusual vaginal bleeding
  16. vomiting blood or material that looks like coffee grounds

Rare

  1. Agitation
  2. anxiety
  3. back pain
  4. bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site
  5. blurred vision
  6. coma
  7. drowsiness
  8. fast, pounding, or irregular heartbeat or pulse
  9. hallucinations
  10. inability to speak
  11. irritability
  12. mood or mental changes
  13. nausea
  14. redness of the skin
  15. seizures
  16. severe headache
  17. slurred speech
  18. stiff neck
  19. temporary blindness
  20. vomiting
  21. weakness in the arm or leg on one side of the body, sudden and severe
  22. welts

Incidence not known

  1. Blistering, peeling, or loosening of the skin
  2. cracks in the skin
  3. joint or muscle pain
  4. loss of heat from the body
  5. red skin lesions, often with a purple center
  6. red, irritated eyes
  7. red, swollen skin
  8. scaly skin
  9. skin blisters

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Abdominal or stomach pain
  2. bruising
  3. constipation
  4. difficult or labored breathing
  5. difficulty with moving
  6. faintness or lightheadedness when getting up from a lying or sitting position
  7. fear
  8. feeling of warmth
  9. full or bloated feeling or pressure in the stomach
  10. joint pain
  11. lack or loss of strength
  12. large, flat, blue or purplish patches in the skin
  13. loss of appetite
  14. muscle aching or cramping
  15. muscle pain or stiffness
  16. nervousness
  17. pain
  18. rash
  19. redness of the face, neck, arms and occasionally, upper chest
  20. runny nose
  21. sleeplessness
  22. sneezing
  23. stuffy nose
  24. sudden or increased sweating
  25. swelling of the abdominal or stomach area
  26. swelling of the hands, ankles, feet, or lower legs
  27. swollen joints
  28. throat irritation
  29. trouble with sleeping
  30. unable to sleep
  31. weight loss

Less common

  1. Acid or sour stomach
  2. belching
  3. heartburn
  4. indigestion
  5. stomach discomfort, upset, or pain
  6. swelling or redness in the joints

For several months after receiving this therapy, it may still produce some side effects that need attention. During this period of time check with your doctor immediately if you notice any of the following:

  1. Bleeding gums
  2. bone pain
  3. headache, sudden and severe
  4. inability to speak
  5. increased menstrual flow or vaginal bleeding
  6. red or black, tarry stools
  7. red or dark brown urine
  8. temporary blindness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: Sept. 01, 2023