Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of digoxin have not been performed in the pediatric population. However, infants are more likely to be very sensitive to the effects of digoxin which may require an individual dose for infants receiving digoxin.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of digoxin in the elderly. However, elderly patients are more likely to have age-related kidney or heart problems which may require caution and an adjustment in the dose for patients receiving digoxin.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Levoketoconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abrocitinib
  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Adagrasib
  • Albuterol
  • Alprazolam
  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Amiodarone
  • Amlodipine
  • Amtolmetin Guacil
  • Asciminib
  • Aspirin
  • Atorvastatin
  • Azithromycin
  • Bemetizide
  • Bendroflumethiazide
  • Benzthiazide
  • Berotralstat
  • Bismuth
  • Boceprevir
  • Bromfenac
  • Bufexamac
  • Buthiazide
  • Calcium
  • Calcium Carbonate
  • Canagliflozin
  • Cannabidiol
  • Capmatinib
  • Captopril
  • Carvedilol
  • Celecoxib
  • Ceritinib
  • Chan Su
  • Chlorothiazide
  • Chlorthalidone
  • Cholestyramine
  • Choline Salicylate
  • Cinnarizine
  • Clarithromycin
  • Clevidipine
  • Clonixin
  • Clopamide
  • Cobicistat
  • Colchicine
  • Colestipol
  • Conivaptan
  • Crizotinib
  • Cyclopenthiazide
  • Cyclosporine
  • Cyclothiazide
  • Daclatasvir
  • Daridorexant
  • Darunavir
  • Demeclocycline
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Diltiazem
  • Dipyrone
  • Dofetilide
  • Dopamine
  • Doxercalciferol
  • Dronedarone
  • Droxicam
  • Elacestrant
  • Elagolix
  • Eliglustat
  • Ephedrine
  • Epinephrine
  • Erdafitinib
  • Erythromycin
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Felodipine
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Fingolimod
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Gentamicin
  • Gilteritinib
  • Hawthorn
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibuprofen
  • Indapamide
  • Indomethacin
  • Isavuconazonium Sulfate
  • Isradipine
  • Itraconazole
  • Ivacaftor
  • Kaolin
  • Ketoprofen
  • Ketorolac
  • Kyushin
  • Lapatinib
  • Lasmiditan
  • Ledipasvir
  • Lenacapavir
  • Lily of the Valley
  • Lorlatinib
  • Lornoxicam
  • Loxoprofen
  • Lumacaftor
  • Lumiracoxib
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Sulfate
  • Magnesium Trisilicate
  • Manidipine
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Methyclothiazide
  • Metoclopramide
  • Metolazone
  • Mifepristone
  • Milnacipran
  • Minocycline
  • Mitapivat
  • Moricizine
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nefazodone
  • Nepafenac
  • Neratinib
  • Nicardipine
  • Nifedipine
  • Niflumic Acid
  • Nilvadipine
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nimodipine
  • Nirmatrelvir
  • Nisoldipine
  • Nitrendipine
  • Norepinephrine
  • Octreotide
  • Oleander
  • Omeprazole
  • Oxaprozin
  • Oxyphenbutazone
  • Oxytetracycline
  • Parecoxib
  • Paroxetine
  • Pheasant's Eye
  • Phenylbutazone
  • Phenytoin
  • Piketoprofen
  • Piroxicam
  • Pirtobrutinib
  • Polythiazide
  • Ponesimod
  • Potassium Phosphate
  • Pranoprofen
  • Proglumetacin
  • Propafenone
  • Propantheline
  • Propyphenazone
  • Proquazone
  • Quinethazone
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ranolazine
  • Rifampin
  • Ritonavir
  • Rofecoxib
  • Rolapitant
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Selpercatinib
  • Simeprevir
  • Simvastatin
  • Siponimod
  • Sodium Bicarbonate
  • Sodium Salicylate
  • Sotagliflozin
  • Sotalol
  • Sotorasib
  • Sparsentan
  • Spironolactone
  • Squill
  • St John's Wort
  • Succinylcholine
  • Sucralfate
  • Sulindac
  • Taurursodiol
  • Telaprevir
  • Telmisartan
  • Tenoxicam
  • Tepotinib
  • Teriparatide
  • Tetracycline
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Tolvaptan
  • Tramadol
  • Trichlormethiazide
  • Trimethoprim
  • Tucatinib
  • Valbenazine
  • Valdecoxib
  • Vandetanib
  • Vemurafenib
  • Venetoclax
  • Verapamil
  • Vibegron
  • Vilazodone
  • Voclosporin
  • Vonoprazan
  • Xipamide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Aminosalicylic Acid
  • Arbutamine
  • Arotinolol
  • Atenolol
  • Azosemide
  • Befunolol
  • Bepridil
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bopindolol
  • Bucindolol
  • Bupranolol
  • Bupropion
  • Canrenoate
  • Carteolol
  • Cascara Sagrada
  • Celiprolol
  • Chloroquine
  • Dilevalol
  • Disopyramide
  • Epoprostenol
  • Esmolol
  • Etravirine
  • Exenatide
  • Flecainide
  • Flibanserin
  • Gatifloxacin
  • Glecaprevir
  • Hydroxychloroquine
  • Indecainide
  • Labetalol
  • Landiolol
  • Lenalidomide
  • Levobunolol
  • Mepindolol
  • Metipranolol
  • Metoprolol
  • Mibefradil
  • Miglitol
  • Mirabegron
  • Nadolol
  • Nebivolol
  • Neomycin
  • Oxprenolol
  • Pancuronium
  • Penbutolol
  • Pibrentasvir
  • Pindolol
  • Practolol
  • Propranolol
  • Rifapentine
  • Roxithromycin
  • Sulfasalazine
  • Talinolol
  • Telithromycin
  • Tertatolol
  • Ticagrelor
  • Timolol
  • Trazodone
  • Velpatasvir

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood vessel disease (e.g., arteriovenous shunt) or
  • Hypocalcemia (low calcium in the blood) or
  • Hypoxia (low oxygen in the blood) or
  • Thyroid disease—Use with caution. Patients with these conditions may be less sensitive or resistant to the effects of digoxin.
  • Electrical cardioversion (a medical procedure)—Dose of digoxin may be reduced 1 to 2 days prior to electrical cardioversion of atrial fibrillation to avoid worsening of the condition.
  • Heart disease (e.g., amyloid heart disease, AV block, constrictive pericarditis, cor pulmonale, heart attack, hypertrophic cardiomyopathy, restrictive cardiomyopathy, sick sinus syndrome, Wolff-Parkinson-White syndrome))—Avoid or use with caution. May make these conditions worse.
  • Hypercalcemia (high calcium in the blood) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood)—Increased risk of digoxin toxicity.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal from the body.
  • Myocarditis or
  • Ventricular fibrillation (heart rhythm problem)—Should not be used in patients with this condition.

Portions of this document last updated: April 01, 2024

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