Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of cyclosporine have not been performed in children receiving organ transplants. However, no pediatric-specific problems have been documented to date.

Appropriate studies have not been performed on the relationship of age to the effects of cyclosporine in children with rheumatoid arthritis or psoriasis. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cyclosporine in the elderly. However, elderly patients are more likely to have high blood pressure or age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving cyclosporine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bosentan
  • Colchicine
  • Dronedarone
  • Elagolix
  • Eliglustat
  • Ezetimibe
  • Grazoprevir
  • Lercanidipine
  • Levoketoconazole
  • Mifepristone
  • Pitavastatin
  • Simvastatin
  • Sitaxsentan

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Abrocitinib
  • Acalabrutinib
  • Aceclofenac
  • Acemetacin
  • Adagrasib
  • Adalimumab
  • Adenovirus Vaccine, Live
  • Afatinib
  • Alefacept
  • Alfalfa
  • Alfentanil
  • Aliskiren
  • Alogliptin
  • Alpelisib
  • Alprazolam
  • Ambrisentan
  • Amifampridine
  • Amiloride
  • Amlodipine
  • Amphotericin B
  • Amprenavir
  • Amtolmetin Guacil
  • Apalutamide
  • Apazone
  • Apixaban
  • Aprepitant
  • Asciminib
  • Aspirin
  • Asunaprevir
  • Atogepant
  • Atorvastatin
  • Avacopan
  • Avapritinib
  • Azilsartan
  • Azilsartan Medoxomil
  • Azithromycin
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Belzutifan
  • Benazepril
  • Benzhydrocodone
  • Berotralstat
  • Betrixaban
  • Bezafibrate
  • Bimekizumab-bkzx
  • Black Cohosh
  • Boceprevir
  • Bosutinib
  • Brigatinib
  • Bromfenac
  • Bromocriptine
  • Budesonide
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Canagliflozin
  • Candesartan
  • Canrenoate
  • Canrenone
  • Capivasertib
  • Capmatinib
  • Captopril
  • Carbamazepine
  • Caspofungin
  • Celecoxib
  • Cenobamate
  • Ceritinib
  • Cerivastatin
  • Cholera Vaccine, Live
  • Cholic Acid
  • Choline Salicylate
  • Cimetidine
  • Ciprofibrate
  • Ciprofloxacin
  • Clarithromycin
  • Clofazimine
  • Clofibrate
  • Clonixin
  • Clopidogrel
  • Clozapine
  • Cobicistat
  • Codeine
  • Conivaptan
  • Crizotinib
  • Cyclophosphamide
  • Dabigatran Etexilate
  • Dabrafenib
  • Daclatasvir
  • Daridorexant
  • Darunavir
  • Dasabuvir
  • Deflazacort
  • Delavirdine
  • Dengue Tetravalent Vaccine, Live
  • Desogestrel
  • Dexamethasone
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Dienogest
  • Diflunisal
  • Digoxin
  • Dihydrocodeine
  • Diltiazem
  • Dipyrone
  • Domperidone
  • Donepezil
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Drospirenone
  • Droxicam
  • Duvelisib
  • Ebola Zaire Vaccine, Live
  • Edoxaban
  • Efavirenz
  • Elacestrant
  • Elexacaftor
  • Eluxadoline
  • Enalaprilat
  • Enalapril Maleate
  • Enasidenib
  • Encorafenib
  • Entrectinib
  • Enzalutamide
  • Eplerenone
  • Eprosartan
  • Erdafitinib
  • Erythromycin
  • Eslicarbazepine Acetate
  • Estetrol
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Etodolac
  • Etofenamate
  • Etoposide
  • Etoricoxib
  • Etravirine
  • Everolimus
  • Fedratinib
  • Felbinac
  • Felodipine
  • Fenofibrate
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fexinidazole
  • Finerenone
  • Flibanserin
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Flurbiprofen
  • Fluvastatin
  • Fluvoxamine
  • Fosamprenavir
  • Fosaprepitant
  • Foscarnet
  • Fosinopril
  • Fosnetupitant
  • Fosphenytoin
  • Fostamatinib
  • Gemfibrozil
  • Gentamicin
  • Gepirone
  • Gestodene
  • Gilteritinib
  • Glecaprevir
  • Hydrocodone
  • Hydroxychloroquine
  • Ibrexafungerp
  • Ibrutinib
  • Ibuprofen
  • Idelalisib
  • Imatinib
  • Indinavir
  • Indomethacin
  • Infigratinib
  • Infliximab
  • Influenza Virus Vaccine, Live
  • Irbesartan
  • Isavuconazole
  • Isavuconazonium Sulfate
  • Istradefylline
  • Itraconazole
  • Ivacaftor
  • Ivosidenib
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lanreotide
  • Lapatinib
  • Larotrectinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lenacapavir
  • Lesinurad
  • Letermovir
  • Levamlodipine
  • Levonorgestrel
  • Lisinopril
  • Lorlatinib
  • Lornoxicam
  • Losartan
  • Lovastatin
  • Loxoprofen
  • Lumacaftor
  • Lumateperone
  • Lumiracoxib
  • Lurbinectedin
  • Mavacamten
  • Measles Virus Vaccine, Live
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Melphalan
  • Meperidine
  • Mestranol
  • Methadone
  • Methotrexate
  • Methylprednisolone
  • Metoclopramide
  • Mibefradil
  • Mirabegron
  • Mitapivat
  • Mitotane
  • Mobocertinib
  • Modafinil
  • Moexipril
  • Momelotinib
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Mumps Virus Vaccine, Live
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Nabumetone
  • Nafcillin
  • Naproxen
  • Nefazodone
  • Nelfinavir
  • Nepafenac
  • Neratinib
  • Netupitant
  • Nevirapine
  • Nicardipine
  • Nifedipine
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nirmatrelvir
  • Nirogacestat
  • Nomegestrol
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Obeticholic Acid
  • Octreotide
  • Olaparib
  • Olmesartan
  • Omaveloxolone
  • Ombitasvir
  • Orlistat
  • Osimertinib
  • Oxaprozin
  • Oxcarbazepine
  • Oxycodone
  • Oxyphenbutazone
  • Ozanimod
  • Pacritinib
  • Palbociclib
  • Palovarotene
  • Parecoxib
  • Paritaprevir
  • Paroxetine
  • Pazopanib
  • Pemigatinib
  • Pentazocine
  • Perindopril
  • Pexidartinib
  • Phenobarbital
  • Phenylbutazone
  • Phenytoin
  • Pibrentasvir
  • Piketoprofen
  • Piperaquine
  • Piroxicam
  • Pirtobrutinib
  • Pixantrone
  • Poliovirus Vaccine, Live
  • Posaconazole
  • Potassium Phosphate
  • Pralsetinib
  • Pranoprofen
  • Pravastatin
  • Primidone
  • Proglumetacin
  • Propafenone
  • Propyphenazone
  • Proquazone
  • Pyrazinamide
  • Quinapril
  • Quinidine
  • Quinine
  • Ramipril
  • Ranitidine
  • Ranolazine
  • Red Yeast Rice
  • Relugolix
  • Repotrectinib
  • Revefenacin
  • Ribociclib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rimegepant
  • Ritlecitinib
  • Ritonavir
  • Rivaroxaban
  • Rofecoxib
  • Roflumilast
  • Rolapitant
  • Rosuvastatin
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Rucaparib
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Sarecycline
  • Schisandra sphenanthera
  • Selpercatinib
  • Selumetinib
  • Silodosin
  • Simeprevir
  • Sirolimus
  • Sirolimus Protein-Bound
  • Smallpox Monkeypox Vaccine, Live Non-Replicating
  • Smallpox Vaccine
  • Sodium Salicylate
  • Sofosbuvir
  • Sonidegib
  • Sotorasib
  • Sparsentan
  • Spirapril
  • Spironolactone
  • St John's Wort
  • Sufentanil
  • Sulfamethoxazole
  • Sulfinpyrazone
  • Sulindac
  • Suvorexant
  • Tacrolimus
  • Taurursodiol
  • Tazemetostat
  • Telaprevir
  • Telithromycin
  • Telmisartan
  • Telotristat Ethyl
  • Tenofovir Alafenamide
  • Tenoxicam
  • Tepotinib
  • Terbinafine
  • Tezacaftor
  • Thioridazine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tobramycin
  • Tocilizumab
  • Tofacitinib
  • Tolfenamic Acid
  • Tolmetin
  • Tolvaptan
  • Topotecan
  • Tramadol
  • Trandolapril
  • Triamterene
  • Trimethoprim
  • Trofinetide
  • Troleandomycin
  • Tucatinib
  • Typhoid Vaccine, Live
  • Ubrogepant
  • Ustekinumab
  • Valdecoxib
  • Valsartan
  • Vancomycin
  • Vandetanib
  • Varicella Virus Vaccine, Live
  • Velpatasvir
  • Vemurafenib
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vibegron
  • Vilazodone
  • Vincristine
  • Vincristine Sulfate Liposome
  • Voclosporin
  • Vonoprazan
  • Vorapaxar
  • Voriconazole
  • Voxelotor
  • Voxilaprevir
  • Yellow Fever Vaccine
  • Zanubrutinib
  • Zavegepant
  • Zolpidem
  • Zoster Vaccine, Live

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetazolamide
  • Allopurinol
  • Amiodarone
  • Amphotericin B Cholesteryl Sulfate Complex
  • Amphotericin B Lipid Complex
  • Amphotericin B Liposome
  • Azathioprine
  • Chloramphenicol
  • Chloroquine
  • Cisapride
  • Clindamycin
  • Clonidine
  • Colesevelam
  • Dalfopristin
  • Danazol
  • Dirithromycin
  • Famotidine
  • Furosemide
  • Glipizide
  • Glyburide
  • Imipenem
  • Josamycin
  • Mercaptopurine
  • Metronidazole
  • Midazolam
  • Miokamycin
  • Norfloxacin
  • Oxypurinol
  • Probucol
  • Quinupristin
  • Repaglinide
  • Sulfadiazine
  • Sulfasalazine
  • Tigecycline
  • Tolterodine
  • Troglitazone
  • Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Pomelo Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, or history of, or
  • Epilepsy (seizures) or
  • Liver disease—This medicine contains alcohol, which can make these conditions worse.
  • Anemia or
  • Bleeding problems or
  • Brain disease (eg, encephalopathy) or
  • Eye or visual problems (eg, papilloedema) or
  • Hyperkalemia (high potassium in the blood) or
  • Hypertension (high blood pressure) or
  • Hyperuricemia (too much uric acid in the blood) or
  • Infection (eg, bacteria, fungus, virus) or
  • Kidney disease or
  • Lymphoma (cancer of the lymph glands) or
  • Seizures, history of or
  • Skin cancer or
  • Thrombocytopenia (low number of platelets)—Use with caution. May make these conditions worse.
  • Cancer or
  • Hypertension (high blood pressure), uncontrolled or
  • Kidney disease—Neoral® should not be used in patients with these conditions.
  • Infection—May decrease body's ability to fight an infection.

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.