Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of clozapine in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clozapine in the elderly. However, elderly patients are more likely to have constipation, trouble passing urine, uncontrolled movements, or age-related liver, kidney, or heart problems, which may require caution in patients receiving clozapine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Bromopride
  • Cisapride
  • Dronedarone
  • Droperidol
  • Fluconazole
  • Ketoconazole
  • Levoketoconazole
  • Mesoridazine
  • Metoclopramide
  • Nelfinavir
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Potassium Citrate
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Abiraterone Acetate
  • Aclidinium
  • Adagrasib
  • Alfentanil
  • Alfuzosin
  • Alprazolam
  • Amantadine
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Amprenavir
  • Anagrelide
  • Apalutamide
  • Apomorphine
  • Aprepitant
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Atazanavir
  • Atropine
  • Azithromycin
  • Bedaquiline
  • Belladonna
  • Benzhydrocodone
  • Benztropine
  • Biperiden
  • Bromazepam
  • Brompheniramine
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Buspirone
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cannabis
  • Capmatinib
  • Carbamazepine
  • Carbinoxamine
  • Carisoprodol
  • Ceritinib
  • Cetirizine
  • Chloroquine
  • Chlorpheniramine
  • Chlorpromazine
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clidinium
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clonazepam
  • Clothiapine
  • Clozapine
  • Cobicistat
  • Codeine
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Cyclopentolate
  • Cyclosporine
  • Cyproheptadine
  • Dabrafenib
  • Daridorexant
  • Darifenacin
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Delavirdine
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dexmedetomidine
  • Dicyclomine
  • Dihydrocodeine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Doxylamine
  • Duloxetine
  • Ebastine
  • Efavirenz
  • Elagolix
  • Encorafenib
  • Enoxacin
  • Entrectinib
  • Enzalutamide
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Esketamine
  • Etrasimod
  • Famotidine
  • Felbamate
  • Fentanyl
  • Fesoterodine
  • Fexinidazole
  • Fingolimod
  • Flavoxate
  • Flecainide
  • Flibanserin
  • Fluoxetine
  • Fluphenazine
  • Fluvoxamine
  • Formoterol
  • Fosamprenavir
  • Fosaprepitant
  • Foscarnet
  • Fosnetupitant
  • Fosphenytoin
  • Fostemsavir
  • Gabapentin
  • Gabapentin Enacarbil
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Gepirone
  • Glasdegib
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Homatropine
  • Hydrocodone
  • Hydromorphone
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Hyoscyamine
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indinavir
  • Inotuzumab Ozogamicin
  • Interferon Alfa-2b
  • Ipratropium
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ketamine
  • Lacosamide
  • Lapatinib
  • Larotrectinib
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Letermovir
  • LetibotulinumtoxinA-wlbg
  • Leuprolide
  • Levocetirizine
  • Levofloxacin
  • Levorphanol
  • Lithium
  • Lofexidine
  • Lomitapide
  • Lopinavir
  • Loxapine
  • Lumacaftor
  • Lumefantrine
  • Macimorelin
  • Magnesium Oxybate
  • Mate
  • Meclizine
  • Mefloquine
  • Mepenzolate
  • Meperidine
  • Methacholine
  • Methadone
  • Methotrimeprazine
  • Metronidazole
  • Mexiletine
  • Mibefradil
  • Mifepristone
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Mizolastine
  • Mobocertinib
  • Moclobemide
  • Moricizine
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nafarelin
  • Nalbuphine
  • Nefazodone
  • Netupitant
  • Nilotinib
  • Nirmatrelvir
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Oliceridine
  • Ondansetron
  • Orphenadrine
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxitropium Bromide
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Pacritinib
  • Palbociclib
  • Paliperidone
  • Panobinostat
  • Papaverine
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Peginterferon Alfa-2a
  • Pentamidine
  • Pentazocine
  • Periciazine
  • Perphenazine
  • Phenobarbital
  • Phenytoin
  • Pimavanserin
  • Pipamperone
  • Pipenzolate Bromide
  • Pirenzepine
  • Pitolisant
  • Pixantrone
  • Ponesimod
  • Potassium Oxybate
  • Pregabalin
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Procyclidine
  • Promethazine
  • Propafenone
  • Propantheline
  • Propiverine
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Quizartinib
  • Ranitidine
  • Ranolazine
  • Relugolix
  • Remifentanil
  • Remimazolam
  • Revefenacin
  • Ribociclib
  • Rifampin
  • Risperidone
  • Ritonavir
  • Rolapitant
  • Ropeginterferon Alfa-2b-njft
  • Scopolamine
  • Secretin Human
  • Selpercatinib
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Sodium Oxybate
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St John's Wort
  • Stramonium
  • Sufentanil
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Tapentadol
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Terbinafine
  • Terodiline
  • Tetrabenazine
  • Thiothixene
  • Tiotropium
  • Tizanidine
  • Tolterodine
  • Topiramate
  • Toremifene
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimipramine
  • Triptorelin
  • Tropicamide
  • Trospium
  • Umeclidinium
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vilanterol
  • Viloxazine
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Vorinostat
  • Voxelotor
  • Zolpidem
  • Zotepine
  • Zuclopenthixol
  • Zuranolone

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice
  • Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Caffeine

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, history of or
  • Blood clotting problems (eg, deep vein thrombosis, pulmonary embolism) or
  • Blood vessel problems (poor circulation) or
  • Dehydration or
  • Head injury, history of or
  • Heart attack, recent or history of or
  • Heart disease (eg, cardiomyopathy, myocarditis) or
  • Heart failure or
  • Heart rhythm problems (eg, arrhythmia, long QT syndrome, slow heart rate), or history of or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low blood volume) or
  • Stroke, history of—May cause side effects to become worse.
  • Diabetes or
  • Difficult urination or
  • Dyslipidemia (high cholesterol or fat in the blood) or
  • Enlarged prostate or
  • Glaucoma, narrow angle or
  • Hyperglycemia (high blood sugar) or
  • Liver disease (eg, hepatitis) or
  • Neuroleptic malignant syndrome, history of or
  • Seizures, history of or
  • Stomach or bowel problems (eg, constipation)—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Phenylketonuria (PKU)—The orally disintegrating tablet contains phenylalanine, which can make this condition worse.

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.