Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Very rarely, use of chymopapain has caused serious side effects, including paralysis of the legs or death. Also, this medicine may cause dangerous allergic reactions, especially in women.

Check with your doctor as soon as possible if any of the following side effects occur:


  1. Abdominal or stomach cramps or pain
  2. changes in facial skin color
  3. constipation (severe)
  4. convulsions (seizures)
  5. decreased or uncontrolled urination
  6. fast or irregular breathing
  7. headache (sudden, severe, and continuing)
  8. hot skin
  9. pain, tenderness, swelling and/or skin color changes of the leg or foot
  10. puffiness or swelling of the eyelids or around the eyes
  11. runny nose
  12. shortness of breath, troubled breathing, tightness in chest, or wheezing
  13. skin rash, redness, hives, or itching
  14. swelling of abdomen or stomach
  15. uncontrolled bowel movements
  16. vomiting
  17. weakness in legs (severe) or problems with moving legs

Other side effects may occur that usually do not need medical attention. Pain and muscle spasms in the lower back may last for several days after you have received this medicine. Stiffness or soreness in the back may last for several months. Other side effects may go away after a short time. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

  1. Back pain, stiffness, or soreness
  2. muscle spasms in lower back

Less common or rare

  1. Cramps, pain, or mild weakness in legs
  2. decreased sensitivity to pain
  3. dizziness
  4. feeling of burning in lower back
  5. foot drop
  6. headache
  7. nausea
  8. numbness or tingling in legs or toes

Check with your doctor as soon as possible if any of the following side effects occur:

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.