原发性胆汁性胆管炎(PBC)

Sept. 24, 2026

研究

妙佑医疗国际对原发性胆汁性胆管炎的研究已有 40 多年的历史,许多治疗该疾病的方法都在这里进行过研究。妙佑医疗国际是最早研究熊去氧胆酸(UDCA)作为治疗方案的中心之一。研究人员目前正在为对 UDCA 仅有部分反应的患者研究新药,包括应用联合疗法。

妙佑医疗国际研究团队为认识原发性胆汁性胆管炎的遗传学机制做出了许多贡献。他们帮助发现了一些基因变异,这些变异似乎会令人更可能患上此疾病。他们的发现是开发靶向治疗并可能治愈该疾病的第一步。

此外,妙佑医疗国际的研究人员还发现,在原发性胆汁性胆管炎患者一级亲属(父母、兄弟姐妹或孩子)的血液中,更有可能含有一种表明该疾病存在的蛋白质。医生将其称为生物标志物。该发现表明,一个简单的血液检查可以帮助医生在一级亲属中及早发现疾病,以便在此病导致不可逆的肝损伤之前开始治疗。

与原发性胆汁性胆管炎及其他肝病有关的基础研究在以下妙佑医疗检测实验室进行:

著述

请参阅美国国家医学图书馆检索服务系统 PubMed 所收录的妙佑医疗国际医生在原发性胆汁性胆管炎领域的著述目录。

  1. Tanaka A, et al. Primary biliary cholangitis. The Lancet. 2024; doi:10.1016/S0140-6736(24)01303-5.
  2. Burt AD, et al., eds. Bile duct diseases. In: MacSween's Pathology of the Liver. 8th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed April 29, 2025.
  3. Ferri FF. Primary billiary cholangitis. In: Ferri's Clinical Advisor 2025. Elsevier; 2025. https://www.clinicalkey.com. Accessed April 29, 2025.
  4. Poupon R. Clinical manifestations, diagnosis, and prognosis of primary biliary cholangitis. https://www.uptodate.com/contents/search. Accessed April 29, 2025.
  5. Primary biliary cholangitis. American College of Gastroenterology. https://gi.org/topics/primary-biliary-cirrhosis-pbc/. Accessed April 29, 2025.
  6. Bhushan S, et al. Primary biliary cholangitis and primary sclerosing cholangitis therapy landscape. American Journal of Gastroenterology. 2025; doi:10.14309/ajg.0000000000003174.
  7. Poupon R. Overview of the management of primary biliary cholangitis. https://www.uptodate.com/contents/search. Accessed April 29, 2025.
  8. Poupon R. Pruritus associated with cholestasis. https://www.uptodate.com/contents/search. Accessed May 6, 2025.
  9. Baer AN. Treatment of dry mouth and other non-ocular sicca symptoms in Sjögren's disease. https://www.uptodate.com/contents/search. Accessed May 14, 2025.
  10. Goldberg E, et al. Cirrhosis in adults: Overview of complications, general management, and prognosis. https://www.uptodate.com/contents/search. Accessed May 16, 2025.
  11. Primary biliary cholangitis (primary billiary cirrhosis). National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/liver-disease/primary-biliary-cholangitis. Accessed May 14, 2025.
  12. Nimmagadda R. Allscripts EPSi. Mayo Clinic. Dec. 3, 2024.